Advances in sleep-related hypermotor epilepsy.
10.3785/j.issn.1008-9292.2020.08.04
- Author:
Jiahui XU
1
;
Bo JIN
2
;
Lisan ZHANG
1
;
Shuang WANG
3
Author Information
1. Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
2. Department of Neurology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
3. Department of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
- Publication Type:Journal Article
- Keywords:
Diagnosis;
Epilepsy;
Nocturnal frontal lobe epilepsy;
Parasomnia;
Pathogenesis;
Sleep-related hypermotor epilepsy;
Therapy
- From:
Journal of Zhejiang University. Medical sciences
2020;49(4):425-430
- CountryChina
- Language:Chinese
-
Abstract:
Sleep-related hypermotor epilepsy (SHE), formerly known as nocturnal frontal epilepsy, is characterized by asymmetrical tonic or complex hypermotor seizures during sleep, with transient, frequent and clustering attack. The accurate incidence is not known but somehow low, which is estimated about 1.8/100 000. The differential diagnosis between SHE and parasomnias may be challenging due to possible similarities between the two sleep-related manifestations. In a majority of patients, the etiology is unknown. Identified etiologies are heterogeneous and structural abnormalities,which are involved in the severity and prognosis of SHE. In terms of treatment, it mainly includes pharmacological therapy and surgery. Carbamazepine seems to be the drug of choice in SHE patients, and epilepsy surgery provides excellent results in selected drug-resistant SHE cases. This review will focus on diagnosis, pathogenesis, treatment and prognosis of SHE, aiming to promote its early diagnosis and appropriate treatment.
