Abnormal eye movements in patients with idiopathic rapid eye movement sleep behavior disorder.
10.3785/j.issn.1008-9292.2020.08.14
- Author:
Yi YANG
1
;
Fei LI
2
;
Yu PAN
3
;
Fei XIE
1
;
Jie CHEN
3
;
Yi SUN
3
;
Xingyue HU
1
;
Lisan ZHANG
1
Author Information
1. Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
2. Department of Neurology, Shanghai Changzheng Hospital, Navy Military Medical University, Shanghai 200003, China.
3. Sleeping Disorder Center, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
- Publication Type:Journal Article
- Keywords:
REM sleep behavior disorder;
Saccades;
Smooth pursuit;
Videonystagmography
- From:
Journal of Zhejiang University. Medical sciences
2020;49(4):447-454
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the characteristics of eye movements in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD).
METHODS:Twenty two patients with iRBD and 20 controls were enrolled between January 2017 and May 2019 from Sir Run Run Shaw Hospital, Zhejiang University School of Medicine. Clinical data including polysomnogram (PSG) results were collected. Videonystagmography (VNG) including spontaneous nystagmus, gaze, saccade, tracking and optokinetic test were performed. The difference of VNG results between iRBD patients and controls were analyzed. The factors related to the abnormal VNG results were analyzed by using logistic regression analysis.
RESULTS:No significant differences were found between the iRBD and control groups in the spontaneous nystagmus, gaze nystagmus, square wave jerk, involuntary eye movement, saccade and optokinetic nystagmus (all >0.05). In smooth pursuit of 0.4-0.5 Hz and 0.6-0.7 Hz, iRBD patients had more type Ⅲ-Ⅳ curve than controls (=5.177 and 5.301, both <0.05). Logistic regression analysis indicated that less sleep time of N3 stage was related to the abnormal results in smooth pursuit of 0.4-0.5 Hz (=0.963, <0.05). iRBD patients with Ⅲ-Ⅳ type curve in smooth pursuit of 0.4-0.5 Hz had less N3 sleep time than iRBD patients with Ⅰ-Ⅱ type curve (52±28 min vs. 76±23 min, =2.197, <0.05).
CONCLUSIONS:Abnormal smooth pursuit was found in iRBD patients, which might be related to the pathological mechanism of iRBD.
