Advances on GABAergic interneurons in autism spectrum disorders.
10.3785/j.issn.1008-9292.2020.08.10
- Author:
Jie LI
1
;
Junyu XU
1
;
Jianhong LUO
1
Author Information
1. School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Journal Article
- Keywords:
Autism spectrum disorders;
Cortex;
GABAergic neurons;
Ion channels;
Receptors
- From:
Journal of Zhejiang University. Medical sciences
2020;49(4):508-513
- CountryChina
- Language:Chinese
-
Abstract:
More and more evidences support that the abnormality of GABAergic interneurons is associated with autism spectrum disorders (ASD), epilepsy, schizophrenia and other neurodevelopmental disorders. In recent years, numerous drugs have been developed to regulate ion channels and receptors in GABAergic interneurons, including sodium channels and N-methyl-D-aspartate (NMDA) receptors. The activators of Na channel can enhance the action potential of GABAergic interneurons by reducing the inactivation of Na channel. NMDA receptor, as a potential therapeutic target of ASD, can restore the NMDA function of GABAergic interneurons, which would be used to treat behavioral defects. In addition, there are many ion channels and receptors on GABAergic interneurons related to ASD. This article reviews GABAergic interneurons in the pathogenesis of ASD and the related interventions.
