Discovery and application of traditional Chinese medicine efficacy markers based on systematic traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20200210.402
- Author:
Meng-Qi HUO
1
;
Sha PENG
1
;
Yue REN
1
;
Zhan SHU
1
;
Yan-Ling ZHANG
1
;
Yan-Jiang QIAO
1
Author Information
1. State Administration of Traditional Chinese Medicine, Research Center of Traditional Chinese Medicine-Information Engineering,Key Technology of Traditional Chinese Medicine Pharmacy and New Drug Development Engineering Research Center of Ministry of Education, School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
- Publication Type:Journal Article
- Keywords:
data mining;
efficacy marker;
network pharmacology;
quality control of traditional Chinese medicine;
systematic traditional Chinese medicine
- MeSH:
Biomarkers;
Drugs, Chinese Herbal;
Medicine, Chinese Traditional;
Quality Control;
Research Design
- From:
China Journal of Chinese Materia Medica
2020;45(14):3245-3250
- CountryChina
- Language:Chinese
-
Abstract:
The quality marker(Q-marker) of traditional Chinese medicine(TCM) is a new concept of TCM quality control proposed in recent years. It is a hot issue in the research of modern Chinese medicine. The TCM efficacy is a high-level summary of the TCM therapeutic effect under the guidance of TCM theory. On this basis, it is of considerable significance to explore the TCM efficacy marker for the TCM modernization. However, the traditional research strategy based on the single herb and decoction piece in macro TCM level, or the drug research strategy based on the biological effect of the targets, is quite different from the characteristics of multiple components of TCM, as well as the weak and low-selective effect of Chinese medicine ingredients on targets. Therefore, how to select representative ingredients to characterize the TCM overall efficacy is a problematic point in establishing TCM efficacy markers. In this paper, the concept and method of Q-marker were introduced into the study of Chinese medicine efficacy. The research method for systematic TCM was used to systematically discuss the connotation of TCM efficacy markers, the principles of discovery and determination, common research ideas and techniques by taking the representative research results as an example. This study provides new ideas for the research and discovery of TCM efficacy markers.
