Structural characteristics of pharmacodynamical components in genuine Moutan Cortex.
10.19540/j.cnki.cjcmm.20200423.303
- Author:
Yun-Qing XIA
1
;
Mao-Mao ZHU
2
;
Ru LI
3
;
Li-Cheng YANG
3
;
Song GAO
4
;
Su-Mei CAO
4
;
Liang FENG
3
;
Xiao-Bin JIA
3
Author Information
1. College of Pharmacy, Jiangsu University Zhenjiang 212013, China School of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 211198, China.
2. School of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 211198, China Nanjing Institute of Product Quality Inspection Nanjing 210023, China.
3. School of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 211198, China.
4. Henan Wanxi Pharmaceutical Co., Ltd. Nanyang 473000, China.
- Publication Type:Journal Article
- Keywords:
Moutan Cortex;
genuine;
pharmacodynamical basis;
structural characteristics of components
- MeSH:
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
Paeonia;
Principal Component Analysis
- From:
China Journal of Chinese Materia Medica
2020;45(14):3351-3359
- CountryChina
- Language:Chinese
-
Abstract:
Guided by the theory of "component structure", we analyzed the structural characteristics of pharmacodynamical components in genuine Moutan Cortex. The compositions of organic small molecules were determined by high performance liquid chromatography(HPLC) for 20 batches of genuine Moutan Cortex and 12 batches of non-genuine Moutan Cortex. By means of similarity analysis, clustering analysis(CA), principal component analysis(PCA) and orthogonal partial least-squares discriminant analysis(OPLS-DA), the elements in structural characteristics of the pharmacodynamical components were extracted as follows: terpene glycosides components(oxidized paeoniflorin, paeoniflorin,galloyl paeoniflorin, benzoyloxy paeoniflorinand benzoyl paeoniflorin), tannin components(1,3,6-tri-O-galloside acyl glucose, pentagalloyl glucose), and phenolic acid components(methyl gallate, paeonol). The contents and quantity ratios of terpene glycoside component, tannin component and phenolic acid components in genuine Moutan Cortex were determined as 14.1, 12.5, 21.7 mg·g~(-1), 1.00∶0.89∶1.54. The contents and quantity ratios of the oxidized paeoniflorin, paeoniflorin and benzoylpaeoniflorin in the terpene glycoside components were characteristic and determined as 2.05, 7.05, 3.30 mg·g~(-1), 1.00∶3.44∶1.61. The unique structural characteristics of genuine Moutan Cortex provide scientific basis for the formulation of quality standards.
