Research progress on antitumor activity of quercetin derivatives.
10.19540/j.cnki.cjcmm.20200428.602
- Author:
Ya-Li FENG
1
;
Ling-Pan LU
1
;
Guang-Yu ZHAI
1
Author Information
1. School of Pharmaceutical and Chemical Engineering, Zhengzhou Institute of Industrial Technology Xinzheng 451150, China.
- Publication Type:Journal Article
- Keywords:
anti-tumor;
complex;
derivative;
ester;
ether;
modification;
quercetin
- MeSH:
Biological Availability;
Humans;
Neoplasms;
Oxidation-Reduction;
Quercetin;
Solubility
- From:
China Journal of Chinese Materia Medica
2020;45(15):3565-3574
- CountryChina
- Language:Chinese
-
Abstract:
Quercetin is a kind of typical flavonoid, mainly found in various vegetables, fruits and Chinese herbs that are consumed daily, with the functions of anti-oxidation, anti-tumor, prevention and treatment of cardiovascular and cerebrovascular diseases. Quercetin is a natural compound with defined anti-tumor activity. Due to its low bioavailability and poor water solubility, quercetin has limitations in clinical application. The quercetin derivatives with good solubility, high bioavailability, metabolic stability, and low toxicity have been obtained through modification of quercetin structure. In recent years, a large number of quercetin ethers, esters, complexes, C-4 carbonyloxy substituted derivatives, A,B-ring modified compounds and other derivatives have been synthesized and tested for in vitro anticancer activity. The quercetin derivatives with anti-tumor activity synthesized in the last 5 years were reviewed in this paper.
