Advances in studies on structure and pharmacological activities of natural tirucallane-type triterpenoids.
10.19540/j.cnki.cjcmm.20200228.202
- Author:
Jun XIE
1
;
Chang-Kang LI
1
;
Jia FU
1
;
Hong-Qing WANG
1
;
Bao-Ming LI
1
;
Ruo-Yun CHEN
1
;
Jie KANG
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
chemical structure;
origin;
pharmacological activity;
tirucallane-type triterpenoids
- MeSH:
Antineoplastic Agents, Phytogenic;
Molecular Structure;
Triterpenes
- From:
China Journal of Chinese Materia Medica
2020;45(15):3617-3630
- CountryChina
- Language:Chinese
-
Abstract:
The tirucallane-type triterpenoids, composed of six isoprene units, belong to a group of tetracyclic triterpenoids. Although the naturally-derived tirucallane-type triterpenoids were found in a small amount, the kind of compounds showed various structures, which consist of apo-type, linear said-chain-type and cyclolike said-chain-type and broad bioactivities, such as cytotoxicity, anti-inflammation, antioxidation and anti-plasmin, etc. This paper summarized origins, structures and bioactivities of tirucallane-type triterpenoids in recent ten years. The future research and exploration of tirucallane-type triterpenoids were discussed and prospected.
