Change laws of water absorption in Chinese herbal pieces and prediction model of relative density for Chinese medicine decoction.
10.19540/j.cnki.cjcmm.20200424.307
- Author:
Lu ZHANG
1
;
Xin-Jing GUI
1
;
Fei MENG
1
;
Meng-di XIE
2
;
Jing YAO
1
;
Xiao-Jia HAO
2
;
Bin YAN
3
;
Hong-Yan CHEN
3
;
Shu-He CHEN
3
;
Chun ZHAO
4
;
Ya-Ting AN
4
;
Xin-Jian YANG
4
;
Xue-Lin LI
5
;
Rui-Xin LIU
6
Author Information
1. Department of Pharmacy, the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China the Level Three Laboratory of Chinese Traditional Medical Preparation of State Administration of Traditional Chinese Medicine Zhengzhou 450000, China Henan Province Engineering Research Center of Clinical Application Modernization of Traditional Chinese Medicine Pieces Zhengzhou 450000, China Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of China, Henan University of Chinese Medicine Zhengzhou 450000, China.
2. Henan University of Chinese Medicine Zhengzhou 450046, China.
3. Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430061, China.
4. Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Tianjin 300120, China.
5. Department of Pharmacy, the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China the Level Three Laboratory of Chinese Traditional Medical Preparation of State Administration of Traditional Chinese Medicine Zhengzhou 450000, China Henan Province Engineering Research Center of Clinical Application Modernization of Traditional Chinese Medicine Pieces Zhengzhou 450000, China Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of China, Henan University of Chinese Medicine Zhengzhou 450000, China Henan University of Chinese Medicine Zhengzhou 450046, China Zhengzhou Joysun Industrial Group Co., Ltd. Zhengzhou 450001, China.
6. Department of Pharmacy, the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China the Level Three Laboratory of Chinese Traditional Medical Preparation of State Administration of Traditional Chinese Medicine Zhengzhou 450000, China Henan Province Engineering Research Center of Clinical Application Modernization of Traditional Chinese Medicine Pieces Zhengzhou 450000, China Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of China, Henan University of Chinese Medicine Zhengzhou 450000, China Henan University of Chinese Medicine Zhengzhou 450046, China.
- Publication Type:Journal Article
- Keywords:
Chinese herbal pieces;
Chinese medicine;
extraction ratio;
mathematical model;
relative density;
water absorption
- MeSH:
Drugs, Chinese Herbal;
Medicine, Chinese Traditional;
Quality Control;
Specific Gravity;
Water
- From:
China Journal of Chinese Materia Medica
2020;45(15):3681-3688
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to explore the change laws of water absorption in Chinese herbal pieces and establish the prediction model of relative density for Chinese medicine compound decoction. Firstly, fitted equations of water absorption and decocting time was established by observing the change laws of water absorption in 36 kinds of Chinese herbal pieces in 12 groups(according to the drug-parts) with decocting time. The r value of the mineral group and other type group was 0.691 2 and 0.663 3, respectively. The r value of the remaining 10 groups was 0.802 2-0.925 4. All P values were less than 0.05(n=21). The formula of the amount of water added was optimized by combining the fitted equations with determined water absorption, and the liquid yield could be controlled in a range of 100%±10%. Secondly, it was determined that the liquid density tester could be used for the rapid determination of relative density of Chinese medicine decoction after methodological study and comparison with the pycnometer method. The linear regression equation between the corrected relative density(y) and extraction ratio(%, x) was built by measuring and analyzing the related parameters such as liquid yield, relative density and extraction ratio in 46 kinds of Chinese herbal pieces. The established equation was y=0.041 3x+1.003 7, r=0.930 9(P <0.01, n=46), with linear range of 1.94%-65.75%. Based on this, the prototype model for predicting relative density of Chinese medicine decoction was established, and the relative densities of 8 Chinese medicine decoctions were within the prediction interval of this model in verification. This study lays a foundation for database construction of Chinese medicine decoction, implementation of personalized decocting mode and rapid quality control of Chinese medicine decoction.
