Joint Multi-modal Parcellation of the Human Striatum: Functions and Clinical Relevance.
10.1007/s12264-020-00543-1
- Author:
Xiaojin LIU
1
;
Simon B EICKHOFF
1
;
Felix HOFFSTAEDTER
1
;
Sarah GENON
1
;
Svenja CASPERS
2
;
Kathrin REETZ
3
;
Imis DOGAN
4
;
Claudia R EICKHOFF
2
;
Ji CHEN
1
;
Julian CASPERS
2
;
Niels REUTER
1
;
Christian MATHYS
5
;
André ALEMAN
6
;
Renaud JARDRI
7
;
Valentin RIEDL
8
;
Iris E SOMMER
9
;
Kaustubh R PATIL
10
Author Information
1. Institute of Neuroscience and Medicine (INM-7, Brain and Behaviour), Research Centre Jülich, Jülich, Germany.
2. Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52428, Jülich, Germany.
3. Department of Neurology, Rheinisch Westfällische Technische Hochschule (RWTH) Aachen University, 52074, Aachen, Germany.
4. Jülich Aachen Research Alliance-BRAIN (JARA) Institute of Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich, Rheinisch Westfällische Technische Hochschule (RWTH) Aachen University, 52074, Aachen, Germany.
5. Department of Diagnostic and Interventional Radiology, Medical Faculty, University of Düsseldorf, 40225, Düsseldorf, Germany.
6. Department of Neuroscience, University Medical Center Groningen, University of Groningen, 9713 AV, Groningen, The Netherlands.
7. SCALab (CNRS UMR9193) & CHU de Lille, Hôpital Fontan, Pôle de Psychiatrie (CURE), Université de Lille, 59037, Lille, France.
8. Departments of Neuroradiology, Nuclear Medicine and Neuroimaging Center, Technische Universität München, 80333, Munich, Germany.
9. Institute of Radiology and Neuroradiology, Evangelisches Krankenhaus, University of Oldenburg, 26129, Oldenburg, Germany.
10. Institute of Neuroscience and Medicine (INM-7, Brain and Behaviour), Research Centre Jülich, Jülich, Germany. k.patil@fz-juelich.de.
- Publication Type:Journal Article
- Keywords:
Connectivity-based parcellation;
Convergent clusters;
Multi-modal;
Parkinson’s disease;
Schizophrenia;
Striatum;
Voxel-based morphometry
- From:
Neuroscience Bulletin
2020;36(10):1123-1136
- CountryChina
- Language:English
-
Abstract:
The human striatum is essential for both low- and high-level functions and has been implicated in the pathophysiology of various prevalent disorders, including Parkinson's disease (PD) and schizophrenia (SCZ). It is known to consist of structurally and functionally divergent subdivisions. However, previous parcellations are based on a single neuroimaging modality, leaving the extent of the multi-modal organization of the striatum unknown. Here, we investigated the organization of the striatum across three modalities-resting-state functional connectivity, probabilistic diffusion tractography, and structural covariance-to provide a holistic convergent view of its structure and function. We found convergent clusters in the dorsal, dorsolateral, rostral, ventral, and caudal striatum. Functional characterization revealed the anterior striatum to be mainly associated with cognitive and emotional functions, while the caudal striatum was related to action execution. Interestingly, significant structural atrophy in the rostral and ventral striatum was common to both PD and SCZ, but atrophy in the dorsolateral striatum was specifically attributable to PD. Our study revealed a cross-modal convergent organization of the striatum, representing a fundamental topographical model that can be useful for investigating structural and functional variability in aging and in clinical conditions.
