A Case of Propylthiouracil-induced Lupus Erythematosus.
- Author:
Chang Ook PARK
1
;
Jawoong GOO
;
Sung Ku AHN
Author Information
1. Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea. skahn@wonju.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Drug-induced lupus erythemtosus;
Graves' disease;
Propylthiouracil
- MeSH:
Adolescent;
Antibodies;
Antibodies, Antinuclear;
Atrophy;
Basement Membrane;
Biopsy;
Complement System Proteins;
DNA;
Exanthema;
Female;
Fluorescent Antibody Technique, Direct;
Graves Disease;
Humans;
Immunoglobulin M;
Lymphocytes;
Pancytopenia;
Propylthiouracil
- From:Korean Journal of Dermatology
2006;44(4):467-469
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 14-year-old girl had a history of Graves' disease and received propylthiouracil (PTU) treatment for 2 years before admission to our hospital. She developed skin rash over her, whole body 1 month before admission, and laboratory examination revealed pancytopenia. Positive antinuclear antibodies, antihistone antibodies and reduced complement levels were noted, although anti-double-stranded DNA and anti-Sm antibodies were negative. A biopsy specimen revealed mild epidermal atrophy and peri-adnexal lymphoid cell infiltration. Linear deposition of IgM along the basement membrane zone was noted by direct immunofluorescence array. After discontinuation of PTU and steroid treatment, eruptions and pancytopenia improved, suggesting drug-induced lupus erythematosus.
