Spike protein in the detection and treatment of novel coronavirus.
10.7507/1001-5515.202002050
- Author:
Yongzhu CHEN
1
;
Feng QIU
2
Author Information
1. Periodical Press of West China Hospital, Sichuan University, Chengdu 610041, P.R.China.
2. Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, P.R.China.
- Publication Type:Journal Article
- Keywords:
antibody;
coronavirus;
spike protein;
vaccine
- MeSH:
Betacoronavirus;
Coronavirus Infections;
diagnosis;
therapy;
Evolution, Molecular;
Humans;
Pandemics;
Pneumonia, Viral;
diagnosis;
therapy;
Spike Glycoprotein, Coronavirus;
analysis
- From:
Journal of Biomedical Engineering
2020;37(2):246-250
- CountryChina
- Language:Chinese
-
Abstract:
Recently a COVID-19 pneumonia pandemic caused by a novel coronavirus 2019-nCoV has broken out over the world. In order to better control the spread of the pandemic, there's an urgent need to extensively study the virus' origin and the mechanisms for its infectivity and pathogenicity. Spike protein is a special structural protein on the surface of coronavirus. It contains important information about the evolution of the virus and plays critical roles in the processes of cellular recognition and entry. In the past decades, spike protein has always been one of the most important objects in research works on coronaviruses closely related to human life. In this review we introduce these research works related to spike proteins, hoping it will provide reasonable ideas for the control of the current pandemic, as well as for the diagnosis and treatment of COVID-19.
