Finite element analysis of determining corneal biomechanical properties in vivo based on Corvis ST.
10.7507/1001-5515.201911081
- Author:
Qiaoyu MENG
1
;
Xiaojun WANG
1
;
Weiyi CHEN
2
;
Xiaona LI
2
;
Rui HE
3
Author Information
1. College of Mechanical and Vehicle Engineering, Taiyuan University of Technology, Taiyuan 030024, P.R.China.
2. College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, P.R.China.
3. Department of Excimer Laser, Shanxi Eye Hospital, Taiyuan 030002, P.R.China.
- Publication Type:Journal Article
- Keywords:
Corvis ST;
biomechanics;
cornea;
finite element model;
laser assisted in situ keratomileusis
- MeSH:
Biomechanical Phenomena;
Cornea;
Corneal Topography;
Finite Element Analysis;
Humans;
Keratomileusis, Laser In Situ;
Myopia
- From:
Journal of Biomedical Engineering
2020;37(4):608-613
- CountryChina
- Language:Chinese
-
Abstract:
The decrease of corneal stiffness is the key factor leading to keratoconus, and the corneal collagen fiber stiffness and fiber dispersion are closely related to the corneal biomechanical properties. In this paper, a finite element model of human cornea based on corneal microstructure, namely collagen fiber, was established before and after laser assisted in situ keratomileusis (LASIK). By simulating the Corvis ST process and comparing with the actual clinical results, the hyperelastic constitutive parameters and corneal collagen fiber stiffness modulus of the corneal material were determined before and after refractive surgery. After LASIK, the corneal collagen fiber stiffness modulus increased significantly, and was highly correlated with central corneal thickness (CCT). The predictive relationship between the corneal collagen fiber stiffness modulus and the corresponding CCT before and after surgery was: = exp(9.14 - 0.009CCT ), = exp(8.82 - 0.008CCT ). According to the results of this study, the central corneal thickness of the patient can be used to estimate the preoperative and postoperative collagen fiber stiffness modulus, and then a personalized corneal model that is more consistent with the actual situation of the patient can be established, providing a theoretical reference for more accurately predicting the safe surgical cutting amount of the cornea.
