Application of scalp electroencephalogram in treatment of refractory epilepsy with vagus nerve stimulation.
10.7507/1001-5515.201909002
- Author:
Xiaoya QIN
1
,
2
;
Yuan YUAN
1
,
2
;
Yan CHEN
3
;
Jianxiang LIAO
4
,
5
;
Sufang LIN
3
;
Zhao YANG
2
;
Luming LI
1
,
6
,
7
,
8
Author Information
1. Precision Medicine & Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, Guangdong 518071, P.R.China
2. National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing 100084, P.R.China.
3. Epilepsy Center, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R.China.
4. Epilepsy Center, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R.China
5. Department of Neurology, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R.China.
6. National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing 100084, P.R.China
7. IDG/McGovern Institute for Brain Research at Tsinghua University, Beijing 100084, P.R.China
8. Institute of Epilepsy, Beijing Institute for Brain Disorders, Beijing 100093, P.R.China.
- Publication Type:Journal Article
- Keywords:
curative effect evaluation;
electroencephalogram;
therapeutic effect prediction;
treatment mechanism;
vagus nerve stimulation
- MeSH:
Drug Resistant Epilepsy;
Electroencephalography;
Humans;
Prospective Studies;
Scalp;
Treatment Outcome;
Vagus Nerve Stimulation
- From:
Journal of Biomedical Engineering
2020;37(4):699-707
- CountryChina
- Language:Chinese
-
Abstract:
Electroencephalogram (EEG) has been an important tool for scientists to study epilepsy and evaluate the treatment of epilepsy for half a century, since epilepsy seizures are caused by the diffusion of excessive discharge of brain neurons. This paper reviews the clinical application of scalp EEG in the treatment of intractable epilepsy with vagus nerve stimulation (VNS) in the past 30 years. It mainly introduces the prediction of the therapeutic effect of VNS on intractable epilepsy based on EEG characteristics and the effect of VNS on EEG of patients with intractable epilepsy, and expounds some therapeutic mechanisms of VNS. For predicting the efficacy of VNS based on EEG characteristics, EEG characteristics such as epileptiform discharge, polarity of slow cortical potential changes, changes of EEG symmetry level and changes of EEG power spectrum are described. In view of the influence of VNS treatment on patients' EEG characteristics, the change of epileptiform discharge, power spectrum, synchrony, brain network and amplitude of event-related potential P300 are described. Although no representative EEG markers have been identified for clinical promotion, this review paves the way for prospective studies of larger patient populations in the future to better apply EEG to the clinical treatment of VNS, and provides ideas for predicting VNS efficacy, assessing VNS efficacy, and understanding VNS treatment mechanisms, with broad medical and scientific implications.
