Research progress on chemical composition and pharmacological effects of Periplocae Cortex and predictive analysis on Q-marker.
10.19540/j.cnki.cjcmm.20200327.202
- Author:
Xue YANG
1
;
Meng-Yu LI
2
;
Chang-Yang YAN
2
;
Zhi-Jun XIAO
2
;
Wei-Qi JIANG
2
;
Xiao-Yu WANG
2
;
Xi-Xi CUI
2
;
Wen-Xian LI
2
;
Ke-Nan YAO
2
;
Chuan-Xin LIU
2
Author Information
1. Department of Pharmacy, Changzhi Medical College Changzhi 046000, China School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100029, China.
2. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100029, China.
- Publication Type:Journal Article
- Keywords:
Periplocae Cortex;
cardiac glycosides;
periplocin;
quality evaluation;
quality marker(Q-marker)
- MeSH:
Biomarkers;
China;
Drugs, Chinese Herbal;
analysis;
Medicine, Chinese Traditional;
Quality Control
- From:
China Journal of Chinese Materia Medica
2020;45(12):2772-2783
- CountryChina
- Language:Chinese
-
Abstract:
Periplocae Cortex is a traditional Chinese medicine in China, which is mainly produced in northeast China, north China, northwest China, southwest China. In recent years, the increasing in-depth research resulted in the discovery of anti-tumor and cardiac pharmacological activities of Periplocae Cortex, which has broad application prospects. On the basis of summarizing chemical components and pharmacological effects, combined with the theoretical system of Q-marker, the quality control components of Periplocae Cortex were predicted from the aspects of the correlation between chemical composition and traditional medicinal properties, traditional efficacy, and new clinical use, plasma composition, measurable composition, storage time by analyzing literature. Among the components, periplocoside, periplocin, periplogenin, 4-methoxy salicylaldehyde showed significant activity, which provides a scientific basis for quality evaluation of Periplocae Cortex.
