Review of chemical constituents, pharmacological effects and clinical applications of Jiaotai Pills and predictive analysis of its quality marker(Q-marker).
10.19540/j.cnki.cjcmm.20200328.201
- Author:
Yu SUN
1
;
Yu-Han YANG
1
;
Jun WANG
1
;
Hai-Qiang JIANG
1
;
Ning CUI
2
;
Ben-Zheng SU
2
;
Zong-Yuan YU
2
Author Information
1. College of Pharmacy, Shandong University of Traditional Chinese Medicine Ji'nan 250335, China.
2. Shandong Institute of Traditional Chinese Medicine Ji'nan 250014, China.
- Publication Type:Journal Article
- Keywords:
Jiaotai Pills;
chemical components;
clinical applications;
pharmacological effects;
quality control;
quality marker(Q-marker)
- MeSH:
Biomarkers;
Drugs, Chinese Herbal;
Quality Control
- From:
China Journal of Chinese Materia Medica
2020;45(12):2784-2791
- CountryChina
- Language:Chinese
-
Abstract:
Jiaotai Pills is a traditional medical prescription to treat the incompatibility of heart and kidney. It has the distinctive functions of heart and kidney communication, sedation and hypnosis, anti-anxiety and depression, as well as the improvement of insulin resistance. However, this pill is broadly used to cure insomnia, anxiety, depression, and diabetes in the contemporary clinical trials. Based on the article, it illustrates the research progress of the chemical ingredients, pharmacological actions, and clinical applications of Jiaotai Pills. With respect to the "five principles" of Q-marker in Chinese medicine, the Q-marker of Jiaotai Pills is comprehensively predicted and analyzed, noting that berberine, epiberberine, coptisine chloride, palmatine chloride, berberine chloride, berberrubine chloride, ferulic acid, cinnamic acid, cinnamaldehyde, proanthocyanidin B2 can be treated as the Q-marker of Jiaotai Pills. In addition, these components of Q-marker have been selected as indicators to provide a significant reference for the quality control and surveillance research of Jiaotai Pills.
