Progress of research on effect and mechanism of Scutellariae Radix on preventing liver diseases.
10.19540/j.cnki.cjcmm.20200224.403
- Author:
Qing-Yun BAI
1
;
Si-Min TAO
1
;
Jin-Hong TIAN
1
;
Chun-Rong CAO
1
Author Information
1. Jiangxi Key Laboratory of Natural Drug Research, College of Chemistry and Bioengineering,Yichun University Yichun 336000, China.
- Publication Type:Journal Article
- Keywords:
Scutellariae Radix;
baicalein;
baicalin;
liver disease;
liver protection;
research progress
- MeSH:
Animals;
Anti-Inflammatory Agents;
Drugs, Chinese Herbal;
Flavonoids;
Medicine, Chinese Traditional;
Scutellaria baicalensis
- From:
China Journal of Chinese Materia Medica
2020;45(12):2808-2816
- CountryChina
- Language:Chinese
-
Abstract:
Scutellariae Radix is a kind of traditional Chinese medicine, which has the functions of heat-clearing and damp-drying, purging fire and detoxifying, hemostasis and miscarriage prevention. Modern pharmacological studies show that Scutellariae Radix has various effects, such as anti-oxidation, anti-inflammatory, liver protection and antiviral microorganisms. By searching the documents in the past ten years, the author has found that Scutellariae Radix and its active components play an important role in protecting the liver. It can prevent and cure liver injuries caused by different reasons, including acute or chronic hepatitis, liver fibrosis and liver cancer. Among all kinds(chemical, immunological, alcoholic, nonalcoholic, viral, ischemia-reperfusion, etc.) of acute or chronic hepatitis, most studies are on CCl_4 induced chemical liver injury. Scutellariae Radix and its active components can significantly reduce the serum transaminase level in hepatitis animals, and reduce the degree of liver pathological damage. The mechanisms include antioxidant stress, anti-inflammatory, anti-apoptosis, inhibition of immunity, anti-virus and regulation of lipid metabolism, etc. Scutellariae Radix and its active components can significantly inhibit the activation of hepatic stellate cells and reduce extracellular matrix, and its anti-fibrosis mechanism involves antioxidation, anti-inflammatory, inducing apoptosis of hepatic stellate cells and so on. Whether in vivo or in vitro, Scutellariae Radix and its active components show a good anti-hepatocarcinoma effect, especially on hepatocarcinoma. Its prevention and treatment mechanisms for hepatocarcinoma mainly include blocking cancer cell cycle, inhibiting cancer cell metastasis, promoting cancer cell apoptosis and inducing autophagy. It can be seen that Scutellariae Radix has multiple functions and mechanisms in liver protection, and has a great development potential. Therefore, this paper reviews the prevention and treatment effects and mechanism of Scutellariae Radix and its components on different liver diseases, in order to provide reference for in-depth study, development and clinical application in the prevention and treatment of liver disease.
