Advances on anti-tumor mechanisms of zerumbone.

Author: Hong YANG ¹ ; Rong-Mei DOU ¹ ; Ting YAO ¹ ; Dao-Peng GUI ¹ ; Xue-Wen JANG ¹ ; Jun-Jun LI ¹ ; Fu-Xing GE ¹ ; Xiao-Li GAO ¹ ; Xing-Yun CHAI ¹
Author Information

1. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100029, China.
Publication Type:Journal Article
Keywords: anti-tumor mechanisms; humulane-type sesquiterpenes; review; zerumbone
MeSH: Antineoplastic Agents; pharmacology; Apoptosis; drug effects; Cell Line, Tumor; Sesquiterpenes; pharmacology
From: China Journal of Chinese Materia Medica 2020;45(12):2817-2826
CountryChina
Language:Chinese
Abstract: Zerumbone(ZER), one of humulane-type sesquiterpenoids, showed its unique advantage against tumor activities. The main underlying mechanisms include inhibiting the growth and proliferation of cancer cells, inducing apoptosis of cancer cells and differentiation of cancer cells, regulating immune function, inhibiting invasion and metastasis of cancer cells, and reversing multidrug resistance of cancer cells. Studies on ZER focusing its cytotoxic or anti-tumor is one of hot topic. Currently, with the increasing studies on ZER, the clarified mechanisms are getting rich. The present paper describes a summary of its anti-tumor mechanism of action and helps to provide significant reference to more in-depth research.