Research progress on anti-atherosclerosis effect and mechanism of flavonoids compounds mediated by macrophages.
10.19540/j.cnki.cjcmm.20200119.403
- Author:
Hong LI
1
;
Lu BAI
2
;
Qin QIN
2
;
Bo-Lin FENG
2
;
Liang ZHANG
2
;
Fei-Yan WEI
2
;
Xiu-Fen YANG
1
Author Information
1. Department of Pharmacology, School of Pharmacy, Guangxi University of Chinese Medicine Nanning 530200, China Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine Nanning 530200, China.
2. Department of Pharmacology, School of Pharmacy, Guangxi University of Chinese Medicine Nanning 530200, China.
- Publication Type:Journal Article
- Keywords:
anti-atherosclerosis;
flavonoids;
macrophages
- MeSH:
ATP Binding Cassette Transporter 1;
Atherosclerosis;
Cholesterol;
Flavonoids;
Foam Cells;
Humans;
Lipoproteins, LDL;
Macrophages
- From:
China Journal of Chinese Materia Medica
2020;45(12):2827-2834
- CountryChina
- Language:Chinese
-
Abstract:
Flavonoids are important active ingredients of traditional Chinese medicine, mainly with cardiovascular, anti-liver injury, antioxidant, antispasmodic, and estrogen-like effects. These compounds have obvious effects on the cardiovascular and cerebrovascular diseases. Macrophage-derived foam cells are the key medium in the process of atherosclerosis(AS). In plaque, allserum lipids, serum lipoproteins, and various pro-or anti-inflammatory stimulating factors, chemokines, and small bioactive molecules can significantly affect the macrophage phenotype and induce stronger pro-inflammatory or anti-inflammatory properties. Studies have shown that some flavonoids can be used for macrophages through different pathways and mechanisms, playing an anti-atherosclerosis effect to different degrees, including promotion of cholesterol efflux from macrophages, anti-foaming of macrophages, inhibition of secretion of inflammatory factors, and antioxidant modified low density lipoprotein(ox-LDL)-induced apoptosis of macrophages. Related gene regulation inclu-ded ATP-binding cassette transporter A1(ABCA1), ATP-binding cassette transporter G1(ABCG1), Toll-like receptor(TLR), and scavenger receptor(SR). In this article, we would review the recent research progress of flavonoids on anti-atherosclerosis effect me-diated by macrophage. It is expected to provide new treatment strategies for AS-related cardiovascular and cerebrovascular diseases, and provide research ideas and development directions for the use of related natural medicines and design of new products.
