Pre-formulation physicochemical properties of component-based Chinese medicine of Qinqi Fengshi Fang.
10.19540/j.cnki.cjcmm.20200328.312
- Author:
Hong-Bo LIU
1
;
Si-Ning XU
1
;
Zhi-Shu TANG
1
;
Jing SUN
1
;
Zhong-Xing SONG
1
;
Chun-Li CUI
1
;
Rui ZHOU
1
;
Xing-Hang CAI
1
;
Jin-Gao YU
1
Author Information
1. Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine Xianyang 712083, China State Key Laboratory of Research and Development of Qin Medicine Characteristic Resources (Cultivation), Shaanxi Research Centre on Discovery & Innovation of New Medicine Xianyang 712083, China.
- Publication Type:Journal Article
- Keywords:
Qinqi Fengshi Fang;
component-based Chinese medicine;
pre-formulation study;
total glycosides of Corni Fructus;
total glycosides of Gentianae Macrophyllae Radix;
total glycosides of Panacis Majoris Rhizome
- MeSH:
Cornus;
Drugs, Chinese Herbal;
Glycosides;
Medicine, East Asian Traditional;
Rhizome
- From:
China Journal of Chinese Materia Medica
2020;45(12):2858-2864
- CountryChina
- Language:Chinese
-
Abstract:
Pre-formulation physicochemical properties of the component-based Chinese medicine of Qinqi Fengshi Fang were investigated to provide a research basis for the design of the dosage form for component-based Chinese medicine of Qinqi Fengshi Fang. The macroporous resin adsorption and refining technology was used to prepare the total glycosides extract of Gentianae Macrophyllae Radix, Panacis Majoris Rhizome and Corni Fructus respectively in the prescription of Qinqi Fengshi Fang. Their physicochemical properties were investigated, including solubility, wettability, hygroscopicity, equilibrium solubility, oil-water partition coefficient, and stability. The results showed that the total glycosides of Gentianae Macrophyllae Radix, Panacis Majoris Rhizome and Corni Fructus all had good solubility and wettability. The solubility index of each total glycoside component was greater than 85%, and the water absorption index was greater than 50%. In the range of pH 2.0-7.4, the equilibrium solubility of three kinds of total glycosides all increased with the increase of pH, showing a consistent change trend of solubility. The hydrophilicity was also suitable and similar. Overall, three kinds of total glycosides showed good stability, but strong hygroscopicity. The degree of hygroscopicity was as follows: total glycosides of Gen-tianae Macrophyllae Radix > total glycosides of Corni Fructus > total glycosides of Panacis Majoris Rhizome. Therefore, the hygroscopi-city needed to be considered in the preparation of the component-based Chinese medicine of Qinqi Fengshi Fang. The excipients and packaging materials can be properly selected to reduce the hygroscopicity of the preparation. This study provides a reference for the dosage form design of the component-based Chinese medicine of Qinqi Fengshi Fang.
