A new lignan glucoside from root of Paeonia lactiflora.
10.19540/j.cnki.cjcmm.20200328.203
- Author:
Wan-Chao ZHONG
1
;
Rui LI
1
;
Huan XIA
2
;
Gui-Yang XIA
2
;
Jing-Fang ZHANG
1
;
Gui-Hua TIAN
3
;
Sheng LIN
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050, China.
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050, China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital,Beijing University of Chinese Medicine Beijing 100700, China.
3. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital,Beijing University of Chinese Medicine Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
NO inhibition activity;
Paeonia lactiflora;
chemical constituents;
lignan glucoside
- MeSH:
Chromatography, High Pressure Liquid;
Glucosides;
Lignans;
Paeonia;
Plant Extracts
- From:
China Journal of Chinese Materia Medica
2020;45(12):2903-2906
- CountryChina
- Language:Chinese
-
Abstract:
A new lignan glucoside,(+)-fragransin A_2-4-O-β-D-glucopyranoside(1), has been isolated from the dry root of Paeonia lactiflora by column chromatography on silica gel, Sephadex LH-20, and MCI-gel resin, as well as preparative RP-HPLC. The structure of the new compound was elucidated by spectroscopic data analysis(MS, UV, IR, CD, 1 D and 2 D NMR) and chemical method. Compound 1 showed moderate inhibition against lipopolysaccharide induced nitric oxide production in RAW264.7 macrophages, with an IC_(50) value of 21.3 μmol·L~(-1).
