Study advance of depressive animal models and its application in traditional Chinese medicines.
10.19540/j.cnki.cjcmm.20200302.402
- Author:
Xue-Xue WANG
1
;
Zhu-Ping TAO
1
;
Ying LI
1
;
Can-Wei LI
2
;
Meng-Ran FAN
1
;
Wei-Hong LIU
3
;
Gui-Ning WEI
4
;
Peng-Fei GAO
5
Author Information
1. College of Pharmacy and Chemistry,Dali University Dali 671000,China.
2. College of Public Health,Dali University Dali 671000,China.
3. Department of Agriculture and Biological Science,Dali University Dali 671000,China.
4. Department of Pharmacology,Guangxi Institute of Chinese Medicine and Pharmaceutical Science Nanning 530022,China.
5. College of Pharmacy and Chemistry,Dali University Dali 671000,China National Joint Engineering Research Center for the Development of Medicinal Special Insects Dali 671000,China Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R & D,Dali University Dali 671000,China.
- Publication Type:Journal Article
- Keywords:
animal model;
application progress;
depression;
traditional Chinese medicine
- MeSH:
Animals;
Antidepressive Agents;
therapeutic use;
Depression;
Disease Models, Animal;
Humans;
Medicine, Chinese Traditional;
Mental Disorders;
drug therapy;
Reproducibility of Results
- From:
China Journal of Chinese Materia Medica
2020;45(11):2473-2480
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a kind of mental disease with main symptoms of low mood and lack of pleasure, which seriously endangers human health. An appropriate depressive animal model is of great significance for the study of depression and new antidepressant drugs, while the suitable selection and matching of experimental animals, modeling methods and evaluation indexes are critical to eva-luate the scientificity and effectiveness of the depressive animal model. The study advance of depressive animal models in the aspects of experimental animal selection, modeling principle and method, characteristics, evaluation indexes and their application in traditional Chinese medicine are summarized through the systematic review of relevant literatures in PubMed, CNKI and other databases. The depressive animal modeling methods utilized in recent studies include stress, glucocorticoid induction, reserpine induction, lipopolysaccharide induction, surgical modeling, gene knockout, joint application modeling methods. Stress method is better to simulate the depressive symptoms of clinical patients, whereas there are some deficiencies, such as long modeling time and large cost. The depressive animal models induced by glucocorticoid, reserpine and lipopolysaccharide have the advantages of short modeling time and good controllability, but with a poor reliability. The pathogenesis of surgical modeling is highly matched with that of clinical depressive patients, whereas it has the defect of long postoperative recovery period. Gene knockout models can be used to study the precise role of specific genes in depression. However, its applicability may be restricted in studies on depression. The joint application modeling method can improve its reliability and accuracy, and attracts more and more attention. This paper provides a reference for the selection of animal models in future studies of pathological mechanism of depression, and screening and evaluation of antidepressant drugs.
