Animal model analysis of knee osteoarthritis based on clinical characteristics of Chinese and Western medicine.
10.19540/j.cnki.cjcmm.20200227.403
- Author:
Yan-Yi WU
1
;
Ming BAI
1
;
Shuo TIAN
1
;
Ming-San MIAO
1
Author Information
1. Henan University of Chinese medicine Zhengzhou 450046, China.
- Publication Type:Journal Article
- Keywords:
animal models;
clinical features;
knee osteoarthritis
- MeSH:
Animals;
Disease Models, Animal;
Humans;
Medicine, Chinese Traditional;
Osteoarthritis, Knee
- From:
China Journal of Chinese Materia Medica
2020;45(11):2481-2485
- CountryChina
- Language:Chinese
-
Abstract:
Knee osteoarthritis(KOA) is a common orthopedic disease. Its main symptoms include pain in the medial knee, aggravated knee pain during walking, limited movement, and joint deformity, which seriously affect the daily life of patients. The replication of animal models consistent with clinical symptoms is the premise of KOA-related experimental research. Based on the clinical characteristics of KOA and Western medicine, this paper discusses the existing KOA animal model, and analyzes the clinical anastomosis of the existing model based on the clinical diagnostic criteria of KOA. Through analysis and comparison, it can be seen that most of the existing modeling methods are single-factor animal models, which have a certain gap with the characteristics of KOA caused by clinical multi-factors and interaction. Moreover, modeling methods are mostly guided by Western medicine, and traditional Chinese medicine pathogenic factors are absent in the modeling process. Only cold stimulation method takes cold and wet into account. In the evaluation of the model, knee swelling, pain and articular rickets were the main evaluation criteria, which were different from the diagnostic criteria of Chinese and Western medicine in KOA. In terms of syndrome differentiation and classification, KOA is divided into kidney vacuity and deficiency of marrow, Yang vacuity and cold coagulation, and blood stasis and arrest in traditional Chinese medicine. The exis-ting animal models often confuse KOA with each other. Only cold stimulation method is used to establish KOA of Yang vacuity and cold coagulation. Therefore, in this paper, based on KOA clinical symptoms between Chinese and Western medicine features, analysis of the existing animal models, for further improving KOA animal models, the standardization of the model to evaluate suggestions, in order to improve the animal models and clinical inosculation between Chinese and Western medicine, the KOA animal model to better serve the scientific research work, promote the related mechanism, pathological changes and drug screening.
