A new antiviral isoquinoline alkaloid from Thalictrum glandulosissimum.

Author: Dian LUO ¹ ; Na LYU ¹ ; Ling-Min LIAO ¹ ; Qian GAO ² ; Yin-Ke LI ¹ ; Jing LI ² ; Xin LIU ² ; Xue-Mei LI ² ; Guang-Yu YANG ¹ ; Yan-Qing YE ³ ; Qiu-Fen HU ¹ ; Miao DONG ³
Author Information

1. College of Chinese National Medicine, Yunnan Minzu University Kunming 650500, China Technology Center, China Tobacco Yunnan Industrial Co., Ltd. Kunming 650106, China.
2. Technology Center, China Tobacco Yunnan Industrial Co., Ltd. Kunming 650106, China.
3. College of Chinese National Medicine, Yunnan Minzu University Kunming 650500, China.
Publication Type:Journal Article
Keywords: Thalictrum glandulosissimum; anti-tobacco mosaic virus activity; isoquinoline alkaloid
MeSH: Alkaloids; Antiviral Agents; Isoquinolines; Thalictrum; Tobacco Mosaic Virus
From: China Journal of Chinese Materia Medica 2020;45(11):2568-2570
CountryChina
Language:Chinese
Abstract: A new isoquinoline alkaloid(1) has been isolated from the whole plant of Thalictrum glandulosissimum by using various chromatographic techniques, including silica gel, sephadex, MCI-gel resin, and RP-HPLC, and its structure was determined as 1-(6-hydroxy-7-methylisoquinolin-1-yl) ethantone by physicochemical properties and spectroscopic data. This compound was evaluated for anti-tobacco mosaic virus(TMV) activity. The results showed that it had prominent anti-TMV activity with inhibition rates of 28.4%. This rate was closed to that of positive control.