Analysis on new research and development ideas and technical points of traditional Chinese medicine for prevention and treatment of chronic heart failure.
10.19540/j.cnki.cjcmm.20200107.402
- Author:
Ren-Qiang MA
1
;
Zhong-Qi YANG
2
;
Jun-Ping KOU
3
;
Bo-Yang YU
3
Author Information
1. Center for Drug Evaluation, Guangzhou Boji Biotechnology Co., Ltd. Guangzhou 510663, China School of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 211198, China.
2. the First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510405, China.
3. School of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 211198, China.
- Publication Type:Journal Article
- Keywords:
chronic heart failure;
cli-nical trials;
clinical needs;
drug evaluation;
research and development of traditional Chinese medicine
- MeSH:
Chronic Disease;
Drugs, Chinese Herbal;
Heart Failure;
Humans;
Medicine, Chinese Traditional;
Quality Control
- From:
China Journal of Chinese Materia Medica
2020;45(11):2720-2724
- CountryChina
- Language:Chinese
-
Abstract:
Chronic heart failure(CHF), a serious and end stage of various heart diseases, is a common chronic cardiovascular disease in the 21 st century. Literature data show that the 5-year mortality rate of hospitalized patients with heart failure is as high as 50%. Nowadays, the development of drugs treating heart failure has become a hot spot, meanwhile, traditional Chinese medicine(TCM) has shown the advantages in the treatment of chronic heart failure. In this article, four stages to develop traditional Chinese medicine for chronic heart failure were proposed. Firstly, discuss and screen ideas and methods with regard to the development of TCM and its prescriptions based on clinical needs. Secondly, study the preparation process and quality control method by referring to the existing clinical background of TCM prescriptions and analyzing the chemical compositions and pharmacological action characteristics of each herb in the prescription. Then, design non-clinical evaluation programs and carry out researches on pharmacodynamics and toxicology by combining the experience of clinical use of TCM prescriptions and future clinical positioning, and gradually adjust and improve the programs during implementation. Finally, conduct clinical trial application(IND) by submitting registration application data which are base on the clinical drug experience, preclinical research pharmacy, main pharmacodynamics, safety test results of the prescription, clinical positioning, and reasonable clinical trial plan designed by the theory of TCM. After passing the IND technical review, the clinical trial study shall be officially launched to achieve the desired results and obtain effective Chinese patent medicines for heart failure treatment.
