Preparation of evodiamine-glycyrrhizic acid micelles with glycyrrhizic acid as carrier and their anti-hepatic fibrosis activity.
10.19540/j.cnki.cjcmm.20200424.304
- Author:
Ying-Guang DENG
1
;
Xue-Li LYU
2
;
Yao-Lu ZHU
2
;
Shi-Chang ZHANG
2
;
Si-Jia LIU
2
;
Bo-Xin ZHAO
2
;
Guo-Feng LI
2
Author Information
1. Nanfang Hospital, Southern Medical University Guangzhou 510515, China The Guangzhou Twelfth Municipal People's Hospital Guangzhou 510620, China.
2. Nanfang Hospital, Southern Medical University Guangzhou 510515, China.
- Publication Type:Journal Article
- Keywords:
anti-hepatic fibrosis;
evodiamine;
glycyrrhizic acid;
micelles
- MeSH:
Animals;
Drug Carriers;
Glycyrrhizic Acid;
Liver Cirrhosis;
Micelles;
Particle Size;
Quinazolines;
Rats;
Solubility
- From:
China Journal of Chinese Materia Medica
2020;45(13):3136-3143
- CountryChina
- Language:Chinese
-
Abstract:
This study aimed to prepare evodiamine-glycyrrhizic acid(EVO-GL) micelles to enhance the anti-hepatic fibrosis activity of evodiamine. Firstly, EVO-GL micelles were prepared with use of thin film dispersion method. With particle size, encapsulation efficiency, loading capacity of micelles and the solubility of evodiamine as the indexes, the effect of different factors on micelles was observed to screen the optimal preparation methods and process. Then the pharmaceutical properties and the therapeutic effects of EVO-GL micelles prepared by optimal process were evaluated on CCl_4-induced hepatic fibrosis. The results showed that the micelles prepared by the thin film dispersion method had an even size, with an average particle size of(130.80±12.40)nm, Zeta potential of(-41.61±3.12) mV, encapsulation efficiency of 91.23%±1.22%, drug loading of 8.42%±0.71%, high storage stability at 4 ℃ in 3 months, and slow in vitro release. Experimental results in the treatment of CCl_4-induced hepatic fibrosis in rats showed that EVO-GL micelles had a synergistic anti-hepatic fibrosis effect, which significantly reduced the liver function index of hepatic fibrosis rats. In conclusion, the EVO-GL micelles prepared with glycyrrhizic acid as a carrier would have a potential application prospect for the treatment of hepatic fibrosis.
