Study on chemical constituents from Mastic (Pistacia lentiscus).
10.19540/j.cnki.cjcmm.20200403.201
- Author:
Wei LIU
1
;
Lin CHEN
2
;
Zhao-Guang WANG
3
;
Hao CUI
3
;
Tao YUAN
4
Author Information
1. Key Labortory of Natural Product Chemistry and Application at Universities of Education Department of Xinjiang Uygur Autonomous Region, Yili Normal University Yining 835000, China Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi 830011, China.
2. Department of Pathology, Armed Police Corps Hospital of Xinjiang Urumqi 830000, China.
3. College of Life Science, Jiangxi Normal University Nanchang 330022, China.
4. Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi 830011, China College of Life Science, Jiangxi Normal University Nanchang 330022, China.
- Publication Type:Journal Article
- Keywords:
Mastic;
chemical constituents;
cytotoxicities;
terpenoids
- MeSH:
Humans;
Magnetic Resonance Spectroscopy;
Phytochemicals;
Pistacia
- From:
China Journal of Chinese Materia Medica
2020;45(13):3169-3174
- CountryChina
- Language:Chinese
-
Abstract:
Phytochemical investigation on the methanolic extract of Mastic by using various chromatographic techniques led to the isolation of 9 compounds. Based on the analysis of spectroscopic data(NMR and MS) and/or comparisons with the data reported in the literature, their structures were elucidated as 3β,8α,13-trihydroxypolypoda-14-methoxy-14-methyl-17,21-diene(1), 4-hydroxymyrtenal(2),3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1, 2-diol(3), 2-oxo-Δ~3-4,5,5-trimethylcyclopentynyl acidic acid(4),(1S,2R,3R,5R)-6,6-dimethyl-4-methylidenebicyclo[3.1.1]-heptane-2,3-diol(5),(4R)-1-methyl-4-(1-hydroxyisopropyl)cyclohexene-6-one(6), 6,6-dimethyl-4-hydroxy[3.1.1]hept-2-ene-2-carboxylic acid(7), 6,6-dimethyl[3.1.1]hept-2-ene-2-carboxylic acid(8), 6,6-dimethyl-4-oxobicyclo[3.1.1]hept-2-ene-2-carboxylic acid(9). Compound 1 is a new compound and 2-9 were isolated from this species for the first time. In vitro cytotoxicity assay results indicated that compounds 1, 6 and 7 showed significant inhibitory effects against human lung cancer cell line A549 with IC_(50) values of 20.4, 25.1 and 22.5 μmoL·L~(-1).
