Meta-analysis of Xiaoer Xiaoji Zhike Oral Liqud combined with azithromycin in treatment of mycoplasma pneumonia in children.
10.19540/j.cnki.cjcmm.20200211.503
- Author:
Tian-Li LI
1
;
Feng-Lan PU
2
;
Yang WU
1
;
Guo-Zhen ZHAO
3
;
Hong-Zheng LI
4
;
Qiu-Xiao MA
5
;
Bo LI
6
Author Information
1. Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing 100700, China.
2. Beijing University of Chinese Medicine Beijing 100029, China.
3. Beijing Hospital of Traditional Chinese Medicine, Capital Medical University Beijing 100010, China.
4. Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing 100053, China.
5. Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
6. Beijing Hospital of Traditional Chinese Medicine, Capital Medical University Beijing 100010, China Beijing Institute of Traditional Chinese Medicine Beijing 100010, China.
- Publication Type:Journal Article
- Keywords:
Meta-analysis;
Xiaoer Xiaoji Zhike Oral Liqud;
azithromycin;
mycoplasma pneumonia;
randomized controlled trials;
systematic review
- MeSH:
Azithromycin;
Child;
Cough;
Drugs, Chinese Herbal;
Humans;
Pneumonia, Mycoplasma
- From:
China Journal of Chinese Materia Medica
2020;45(9):2193-2202
- CountryChina
- Language:Chinese
-
Abstract:
Systematic evaluation of the effectiveness and safety of Xiaoer Xiaoji Zhike Oral Liqud combined with azithromycin in the treatment of mycoplasma pneumonia in children. Clinical literatures were retrieved from PubMed, Cochrane Library, EMbase, VIP, CNKI, SinoMed, WanFang from inception to September 2019. Two reviewers independently screened out the literatures, extracted data and assessed the risk of bias of the included studies. Then, Meta-analysis was performed by RevMan 5.3 software. A total of 17 RCT were included, involving 1 712 patients. In this study, there were two subgroups by the application approach of azithromycin: oral azithromycin subgroup and intravenous azithromycin subgroup. According to Meta-analysis results, in terms of the alleviation of clinical symptoms and signs, such as shortening of antifebrile time, cough disappeared time, rales disappearance time, and lung X-ray infiltrating shadow disappearance time, Xiaoer Xiaoji Zhike Oral Liquid combined with oral azithromycin or intravenous azithromycin were better than single-dose azithromycin; in the aspect of the improvement of the overall effective rate, the two combination subgroups were better than the single-use azithromycin; In terms of the decline of IgM, the combination subgroups were also more efficient than the single-use azithromycin, with statistically significant differences. In terms of the incidence of adverse reactions, there was no significant difference between the two combination subgroups and the single-use azithromycin in children, and no serious adverse reactions were found. In inclusion, Xiaoer Xiaoji Zhike Oral Liquid combined with azithromycin can improve the clinical efficacy in treating pediatric mycoplasma pneumonia, with a high safety. Due to the limited quantity and quality of the included studies, more high-quality studies are needed to verify the above conclusion.
