Mechanism of Xuanfei Baidu Tang in treatment of COVID-19 based on network pharmacology.
10.19540/j.cnki.cjcmm.20200325.401
- Author:
Yi WANG
1
;
Xiang LI
2
;
Jun-Hua ZHANG
3
;
Rui XUE
1
;
Jing-Yang QIAN
1
;
Xiao-Hui ZHANG
1
;
Han ZHANG
3
;
Qing-Quan LIU
4
;
Xiao-Hui FAN
1
;
Yi-Yu CHENG
5
;
Bo-Li ZHANG
3
Author Information
1. Department of Chinese Medicine Science & Engineering, Zhejiang University Hangzhou 310058, China.
2. School of Basic Medical Sciences & Forensic Medicine, Hangzhou Medical College Hangzhou 310053, China.
3. State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine Tianjin 300193, China.
4. Beijing Hospital of Traditional Chinese Medicine Beijing 100010, China.
5. Department of Chinese Medicine Science & Engineering, Zhejiang University Hangzhou 310058, China State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine Tianjin 300193, China.
- Publication Type:Journal Article
- Keywords:
Xuanfei Baidu Tang(XFBD);
coronavirus disease 2019(COVID-19);
energy metabolism;
hepatic and biliary metabolism;
immunity and inflammation;
network pharmacology
- MeSH:
Betacoronavirus;
Coronavirus Infections;
drug therapy;
Drugs, Chinese Herbal;
therapeutic use;
Humans;
Medicine, Chinese Traditional;
Pandemics;
Pneumonia, Viral;
drug therapy
- From:
China Journal of Chinese Materia Medica
2020;45(10):2249-2256
- CountryChina
- Language:Chinese
-
Abstract:
The study aimed to investigate the multi-constituent, multi-target mechanism of Xuanfei Baidu Tang(XFBD) in the treatment of coronavirus disease 2019(COVID-19), through exploring the main ingredients and effective targets of XFBD, as well as analyzing the correlation between XFBD targets and COVID-19. The compounds of each herb in XFBD were collected from TCM-PTD, ETCM, TCMSP and SymMap database. Next, the information of meridian tropisms was collected from Chinese Pharmacopoeia(2015 edition), and the target information of the major constituents of XFBD were obtained from TCM-PTD, ETCM, TCMSP and TargetNet database. Subsequently, the target network model and the major modules were generated by Cytoscape, and the functional enrichment analysis of XFBD targets were completed by DAVID and STRING. As a result, ten of the 13 herbs in XFBD belonged to the lung meridian, and 326 of the 1 224 putative XFBD targets were associated with the disease target of COVID-19, among which 109 targets were enriched in the disease pathways of viral infection and lung injury. The main biological pathways regulated by the key XFBD targets included viral infection, energy metabolism, immunity and inflammation, parasites and bacterial infections. In conclusion, the therapeutic mechanism of XFBD in COVID-19 showed a multi-herb, multi-constituent, multi-target pattern, with lung as the chief targeted organ. By regulating a series of biological pathways closely related to the occurrence and development of diseases, XFBD plays a role in balancing immunity, eliminating inflammation, regulating hepatic and biliary metabolism and recovering energy metabolism balance.
