Natural products as potent inhibitors of hypoxia-inducible factor-1α in cancer therapy.
10.1016/S1875-5364(20)60008-5
- Author:
Jin-Cheng ZHONG
1
,
2
;
Xiao-Bo LI
1
,
2
;
Wen-Yu LYU
3
;
Wen-Cai YE
1
,
4
;
Dong-Mei ZHANG
1
,
5
Author Information
1. College of Pharmacy, Jinan University, Guangzhou 510632, China
2. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China.
3. College of Pharmacy, Jinan University, Guangzhou 510632, China.
4. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China. Electronic address: chywc@aliyun.com.
5. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou 510632, China. Electronic address: dmzhang701@jnu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Anticancer treatment;
Cancer;
Hypoxia;
Hypoxia-inducible factor-1α;
Natural products
- From:
Chinese Journal of Natural Medicines (English Ed.)
2020;18(9):696-703
- CountryChina
- Language:English
-
Abstract:
Hypoxia is a prominent feature of tumors. Hypoxia-inducible factor-1α (HIF-1α), a major subunit of HIF-1, is overexpressed in hypoxic tumor tissues and activates the transcription of many oncogenes. Accumulating evidence has demonstrated that HIF-1α promotes tumor angiogenesis, metastasis, metabolism, and immune evasion. Natural products are an important source of antitumor drugs and numerous studies have highlighted the crucial role of these agents in modulating HIF-1α. The present review describes the role of HIF-1α in tumor progression, summarizes natural products used as HIF-1α inhibitors, and discusses the potential of developing natural products as HIF-1α inhibitors for the treatment of cancer.
