Prevalence and Clinical Associations of Lupus Anticoagulant, Anticardiolipin Antibodies, and Anti-beta2-glycoprotein I Antibodies in Patients with Systemic Lupus Erythematosus.
10.3343/kjlm.2010.30.1.38
- Author:
Kwang Sook WOO
1
;
Kyung Eun KIM
;
Jeong Man KIM
;
Jin Yeong HAN
;
Won Tae CHUNG
;
Kyeong Hee KIM
Author Information
1. Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, Korea. progreen@dau.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
lupus erythematosus;
Antiphospholipid antibodies;
Antiphospholipid syndrome
- MeSH:
Adolescent;
Adult;
Antibodies, Anticardiolipin/*blood;
Antibodies, Antiphospholipid/*blood;
Cohort Studies;
Female;
Humans;
Immunoglobulin G/blood;
Immunoglobulin M/blood;
Lupus Coagulation Inhibitor/*blood;
Lupus Erythematosus, Systemic/epidemiology/*immunology;
Male;
Middle Aged;
Pregnancy;
Prevalence;
Retrospective Studies;
Risk Factors;
Venous Thrombosis/epidemiology/immunology
- From:The Korean Journal of Laboratory Medicine
2010;30(1):38-44
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The presence of antiphospholipid antibodies (aPLs) is associated with the clinical features of antiphospholipid syndrome (APS), which comprises venous and arterial thrombosis and pregnancy loss, and systemic lupus erythematosus (SLE). The prevalence of aPLs has been reported to be different in patient populations affected by either of these conditions. We performed a retrospective study to evaluate the prevalence and clinical associations of aPLs, including lupus anticoagulant (LAC), anticardiolipin (aCL), and anti-beta2-glycoprotein I antibodies (anti-beta2-GPI) in a cohort of Korean patients with SLE. METHODS: This study included samples from 88 SLE patients for whom aPL testing had been advised between June 2006 and July 2009 at the Dong-A University Hospital. Serum and plasma samples were tested for LAC, aCL (IgG, IgM), and anti-beta2-GPI (IgG, IgM) antibodies. Clinical data from patients were obtained from a review of medical records. RESULTS: LAC was the most common (34.1% of total patients, 30/88) antibody, followed by IgM aCL (31.8%, 28/88), IgG aCL (18.2%, 16/88), and IgM and IgG anti-beta2-GPI (both 5.7%, 5/88 each). Positivity for LAC was strongly associated with venous/arterial thrombosis (P=0.002). CONCLUSIONS: LAC was the most common antibody detected in Korean SLE patients and is shown to have a significant association with the presence of venous/arterial thrombosis. The measurement of LAC may be clinically useful in identifying patients with SLE who are at a high risk for venous/arterial thrombosis.
