The Relationship between Lewis/Secretor Genotypes and Serum Carbohydrate Antigen 19-9 Levels in a Korean Population.
10.3343/kjlm.2010.30.1.51
- Author:
Hyung Doo PARK
1
;
Kyoung Un PARK
;
Junghan SONG
;
Chang Seok KI
;
Kyou Sup HAN
;
Jin Q KIM
Author Information
1. Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Lewis genotype;
Lewis/Secretor genotype;
CA 19-9;
Korean population
- MeSH:
Adult;
Aged;
Alleles;
Asian Continental Ancestry Group/*genetics;
CA-19-9 Antigen/*blood;
Chemiluminescent Measurements/methods;
Female;
Gene Frequency;
Genotype;
Humans;
Immunoassay/methods;
Lewis Blood-Group System/*genetics;
Male;
Middle Aged;
Phenotype;
Polymorphism, Genetic;
Republic of Korea
- From:The Korean Journal of Laboratory Medicine
2010;30(1):51-57
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The Lewis histo-blood group system consists of 2 major antigens-Lea and Leb-and a sialyl Lewis antigen-carbohydrate antigen (CA) 19-9. We investigated the distribution of Lewis genotypes and evaluated the relationship between the Lewis/Secretor genotypes and the serum level of CA 19-9 in a Korean population to identify whether the serum CA 19-9 levels are influenced by the Lewis/Secretor genotypes. METHODS: The study included 242 individuals who had no malignancies. Lewis genotyping was performed for the 59T>G, 508G>A and 1067T>A polymorphic sites. The Secretor genotype was determined through analysis of the 357C>T and 385A>T polymorphic sites and the fusion gene. Serum CA 19-9 level was analyzed using an electrochemiluminescence immunoassay. RESULTS: Individuals carrying the 3 common genotypes-Le/Le, Le/le(59,508), and Le/le(59,1067)-accounted for 95% of the study population. In the Korean population, the allelic frequencies of Le, Le(59), le(59,508), and le(59,1067) were 0.731, 0.010, 0.223, and 0.035, respectively. We found a significant difference in serum CA 19-9 concentrations among the 9 Lewis/Secretor genotype groups (P<0.001). The serum CA 19-9 levels in subjects with genotype groups 1 and 2 (Le/- and se/se) were higher than those with genotype groups 3-6 (Le/- and Se/-; 15.63 vs 6.64 kU/L, P<0.001). CONCLUSIONS: Le/Le, Le/le(59,508), and Le/le(59,1067) are frequent Lewis genotypes in Koreans. Because serum CA 19-9 levels are significantly influenced by the Lewis/Secretor genotypes, caution is suggested when interpreting the serum CA 19-9 levels.
