Involvement of long non-coding RNAs in the pathogenesis of rheumatoid arthritis.
10.1097/CM9.0000000000000755
- VernacularTitle:Involvement of long non-coding RNAs in the pathogenesis of rheumatoid arthritis
- Author:
Min-Xi LAO
1
;
Han-Shi XU
Author Information
1. Department of Rheumatology and Immunology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
- Publication Type:Journal Article
- From:
Chinese Medical Journal
2020;133(8):941-950
- CountryChina
- Language:English
-
Abstract:
Long non-coding RNA (lncRNA) plays a contributory role in rheumatoid arthritis (RA). In this review, we summarized the current findings of lncRNAs in RA, including cellular function and the potential mechanisms. Serum lncRNA levels are associated with serum proinflammatory cytokines and disease activity. LncRNAs regulate proliferation, migration, invasion and apoptosis of RA fibroblast-like synoviocytes (FLSs), modulate the differentiation of T lymphocytes and macrophages, and affect bone formation-destruction balance of chondrocytes. Besides, lncRNAs are involved in inflammation and cell motivation signaling pathways. In-depth research on lncRNAs may help elucidate the pathogenesis of RA and provides clues for novel treatment targets.
