Research progress on circular RNA in oral squamous cell carcinoma.

Author: Ke-Xin LEI ¹ ; He-Tian BAI ¹ ; Song-Yue YANG ² ; Jing LI ¹ ; Qian-Ming CHEN ¹
Author Information

1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
2. West China Clinical Medicine School, Sichuan University, Chengdu 610041, China.
Publication Type:Journal Article
Keywords: biogenesis of circRNA; biology function; biomarker; circular RNA; oral squamous cell carcinoma
MeSH: Carcinoma, Squamous Cell; Humans; Mouth Neoplasms; RNA; RNA, Circular
From: West China Journal of Stomatology 2020;38(4):425-430
CountryChina
Language:Chinese
Abstract: Circular RNA, a non-coding RNA that forms a covalently closed continuous loop, exists widely in eukaryotic cells. The biogenesis and biological function of this type of RNA indicate that it can play a crucial role in diseases such as tumors, neural system diseases, and cardiovascular diseases; moreover, this RNA may have great potential use as a biomarker in these diseases. Oral squamous cell carcinoma (OSCC) is a common malignancy in oral surgery that is difficult to cure, metastasizes easily, and has poor prognosis. In this review, we summarize the loop-forming mechanisms and functions of circular RNA and describe the progress of current research in the development of oral cancer.