Research progress of Candida albicans on malignant transformation of oral mucosal diseases.
- Author:
Min LIAO
1
;
Lei CHENG
1
;
Xue-Dong ZHOU
1
;
Biao REN
1
Author Information
- Publication Type:Journal Article
- Keywords: Candida albicans; acetaldehyde; inflammation; interleukin-17; nitrosamines; oral cancer
- MeSH: Animals; Candida albicans; Carcinogenesis; Mouth Diseases; Mouth Mucosa; Mouth Neoplasms
- From: West China Journal of Stomatology 2020;38(4):431-437
- CountryChina
- Language:Chinese
- Abstract: Oral cancer is the most common malignant tumor in the head and neck, and is one of the world's top ten malignancies. Microbial infection is an important risk factor of oral cancer. Candida albicans is the most popular opportunistic fungal pathogen. Epidemiological studies have shown that Candida albicans is closely tied to oral malignancy. Animal experimentation have also proven that infection of Candida albicans can promote the development of oral epithelial carcinogenesis. The current studies have revealed several mechanisms involved in this process, including destroying the epithelial barrier, producing carcinogenic substances (nitrosamines, acetaldehyde), inducing chronic inflammation, activating immune response, etc. However, current researches on mechanisms are still inadequate, and some hypotheses remain controversial. Here, we review the findings related to Candida albicans' effect on the malignant transformation of oral mucosa, hoping to provide reference for deep research and controlling oral cancer clinically.
