Protective Effects of Salvianolate on Myocardial Injury or Myocardial Infarction after Elective Percutaneous Coronary Intervention in NSTE-ACS Patients: A Randomized Placebo-Controlled Trial.
10.1007/s11655-020-2728-0
- Author:
Yang OU
1
;
Sheng-Jia SUN
1
;
Hai-Ming SHI
1
;
Jian-Feng LUO
2
;
Xin-Ping LUO
1
;
Yun-Zhi SHEN
1
;
Yu-Fei CHEN
1
;
Wei-Hu FAN
1
;
Hong-Ying LIU
3
;
Wei SHEN
4
Author Information
1. Department of Cardiovascular Disease, Huashan Hospital, Fudan University, Shanghai, 200040, China.
2. Department of Biostatistics, School of Public Health, Fudan University, Shanghai, 200032, China.
3. Medical Department, Shanghai Green Valley Pharmaceutical Co., Ltd., Shanghai, 201203, China.
4. Department of Cardiovascular Disease, Huashan Hospital, Fudan University, Shanghai, 200040, China. drshenwei@163.com.
- Publication Type:Journal Article
- Keywords:
acute coronary syndrome;
myocardial infarction;
percutaneous coronary intervention;
salvianolate
- From:
Chinese journal of integrative medicine
2020;26(9):656-662
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To evaluate the protective effects of salvianolate on percutaneous coronary intervention (PCI) related myocardial injury or myocardial infarction after elective PCI in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients.
METHODS:A total of 149 patients with NSTE-ACS who underwent elective PCI were enrolled. The patients were randomly allocated in a 1:1 ratio to the salvianolate group (74 cases) or the control group (75 cases). After exclusion criteria of coronary angiography, 60 patients with PCI therapy remained in the salvianolate group and 68 in the control group. The incidence and the severity of PCI related myocardial injury or myocardial infarction, in addition to major adverse cardiac events (MACEs) during 1 year follow-up after PCI were studied between the two groups. Multivariate logistic regression analysis was used to determine the independent factors for PCI related myocardial injury or myocardial infarction after elective PCI.
RESULTS:Compared with the control group, salvianolate treatment reduced the incidence of PCI related severe myocardial injury or myocardial infarction (11.7% vs. 26.5%, P=0.035). The rate of MACEs or all-cause death within 1 month or 1 year after the procedure was not significantly different between the two groups.
CONCLUSIONS:Periprocedural treatment with salvianolate reduces the incidence of PCI related severe myocardial injury or myocardial infarction, although it does not influence clinical prognosis. [Chinese clinical trial registry: ChiCTR1800016992].
