Effect of Essential Oil of Zhumeria majdae on Morphine Tolerance and Dependence in Mice.
10.1007/s11655-020-3424-9
- Author:
Zahra EHTEMAMI
1
;
Hamed SHAFAROODI
2
;
Jinous ASGARPANAH
3
Author Information
1. Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
3. Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. taxolfa@yahoo.com.
- Publication Type:Journal Article
- Keywords:
Zhumeria majdae;
dependence;
morphine;
tolerance
- From:
Chinese journal of integrative medicine
2020;26(9):683-687
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To evaluate the effects of Zhumeria majdae essential oil (ZMEO) on morphine dependence and tolerance in mice.
METHODS:ZMEO (10, 20, and 40 mg/kg) and clonidine (0.1 mg/kg) as the positive control were injected intraperitoneally (i.p.). The effect of ZMEO and clonidine on the dependence were evaluated by counting the number of jumps induced by naloxone (5 mg/kg) while the tolerance was evaluated by the tail-flick test.
RESULTS:ZMEO at the dose of 10 mg/kg during the development period led to a significant inhibition of morphine tolerance (P<0.01), while it led to reduced morphine dependence with the doses of 20 and 40 mg/kg. ZMEO at two dose levels of 20 and 40 mg/kg indicated significant antinociceptive activity (P>0.01), and significantly reduced the withdrawal signs (number of jumps) of mice (P>0.01).
CONCLUSIONS:ZMEO had significant effects on morphine tolerance and dependence. The linalool rich essential oil of Z. majdae plays a major role in the reduction of tolerance and dependence induced by morphine.
