Research advance in Randall plaque of kindey stone.
10.11817/j.issn.1672-7347.2020.190575
- Author:
Yongchao LI
1
;
Yang LI
2
Author Information
1. Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China. liyongchao1740@163.com.
2. Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China. liyang7365@163.com.
- Publication Type:Journal Article
- Keywords:
ABCC6;
Randall plaque;
kidney stones;
long non-coding RNA
- MeSH:
Humans;
Kidney;
Kidney Calculi;
Multidrug Resistance-Associated Proteins;
Mutation;
Plaque, Atherosclerotic;
Pseudoxanthoma Elasticum;
Vascular Calcification
- From:
Journal of Central South University(Medical Sciences)
2020;45(4):435-439
- CountryChina
- Language:English
-
Abstract:
Urinary calculi are characterized by high incidence and recurrence rate, which is a challenge in urology. The theory of Randall plaque is widely recognized by scholars. The mechanism of Randall plaque formation includes vascular calcification, osteogenic transformation and so on. However, it still lacks a unified theory for the Randall plaque formation. As an important type of non-coding RNA, long non-coding RNA (lncRNA) is closely related to the occurrence and progress of many diseases. The difference in lncRNA expression between the renal papillary tissues of non-calculous patients and the renal papillary tissues of Randall plaque in renal calculous patients suggests that lncRNA may be involved in the formation of Randall plaque. Pseudoxanthoma elasticum is a rare autosomal recessive hereditary disease, caused by a mutation in the ABCC6 gene. Patients with pseudoxanthoma elasticum have a high prevalence of calculi, and plaque formation is observed in the patient's kidney, which may suggest that mutation in the ABCC6 gene might be involved in the formation of Randall plaque.
