Implication of vacA s1 Genotype of Helicobacter pylori in Children.
- Author:
Yae Jean KIM
1
;
Hae Young PARK
;
Mi Ae LEE
;
Jeong Wan SEO
Author Information
1. Department of Pediatrics, Ewha Womans University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Helicobactoer pylori;
vacA s1;
cagA;
Children
- MeSH:
Bacteria;
Biopsy;
Child*;
Genotype*;
Helicobacter pylori*;
Helicobacter*;
Humans;
Inflammation;
Metaplasia;
Peptic Ulcer;
Polymerase Chain Reaction
- From:Journal of the Korean Pediatric Society
1999;42(11):1516-1523
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Recently vacA s1 genotype of Helicobacter pylori was known to be associated with enhanced inflammation and peptic ulceration. To evaluate the association of the vacA s1 genotype with enhanced inflammation and peptic ulceration in children, we performed a polymerase chain reaction(PCR) for vacA s1 genotype. METHODS: Twenty-seven CLO test-positive children were enrolled. They also revealed histological detection of bacteria and positive ureC gene by PCR in gastric biopsy specimens. The vacA s1, s2 and cagA genotypes were assayed by PCR in gastric biopsy specimens. RESULTS: There were no association between vacA s1 genotype with peptic ulceration, severe inflammatory reaction, histological density of H. pylori, and formation of lymphoid follicle. None of our patients showed intestinal metaplasia. The vacA s1 genotype with or without cagA gene was not associated with peptic ulceration and enhanced inflammation. CONCLUSION: This study suggested that vacA s1 genotype of H. pylori was not associated with peptic ulceration and enhanced inflammation in Korean children.
