Cerebral infarction as the first symptom in acute promyelocytic leukemia: A case report and literature review.
10.11817/j.issn.1672-7347.2020.190008
- Author:
Chengchen ZHAO
1
;
Xiaohui XIE
2
;
Dongzheng GE
3
;
Dengshu WU
3
;
Qiying XIE
4
;
Hongya XIN
5
;
Tianlun YANG
6
Author Information
1. Department of Cardiovascular, Xiangya Hospital, Central South University, Changsha 410008, China. 11918203@zju.edu.cn.
2. Department of Nephology, Xiangya Hospital, Central South University, Changsha 410008, China.
3. Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China.
4. Department of Cardiovascular, Xiangya Hospital, Central South University, Changsha 410008, China.
5. Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China. xinhongya@163.com.
6. Department of Cardiovascular, Xiangya Hospital, Central South University, Changsha 410008, China. tianluny@163.com.
- Publication Type:Case Reports
- Keywords:
acute promyelocytic leukemia;
cerebral infarction;
differentiation syndrome;
disseminated intravascular coagulation;
pulmonary embolism
- MeSH:
Blood Coagulation;
Cerebral Infarction;
Disseminated Intravascular Coagulation;
etiology;
Humans;
Leukemia, Promyelocytic, Acute;
complications;
Thrombosis
- From:
Journal of Central South University(Medical Sciences)
2020;45(4):476-480
- CountryChina
- Language:English
-
Abstract:
In the clinical settings, disseminated intravascular coagulation (DIC) and complications such as hemorrhage are commonly seen in acute promyelocytic leukemia patients, whereas thrombosis is rarely reported. We reported a case here that the patient presented with cerebral infarction as the first manifestation. During the admission, the patient encountered differentiation syndrome, pulmonary embolism, pulmonary hemorrhage, and myocardial ischemia, as well as bleeding and thrombosis complications. Hence the patient was diagnosed as DIC. After the treatment of blood transfusion instead of anticoagulation, his condition was stable and the remission was completely achieved. The treatment experience provides guides for other patients with similar complications of simultaneous bleeding and thrombosis.
