Clinical characteristics of 71 patients with coronavirus disease 2019.
10.11817/j.issn.1672-7347.2020.200187
- Author:
Miaomiao XIAO
1
;
Mingjie HOU
2
;
Xuhui LIU
2
;
Zhe LI
2
;
Qingxia ZHAO
3
Author Information
1. Sixth Department of Infectious Diseases, Sixth People's Hospital of Zhengzhou, Zhengzhou 450015, China. 23617316@qq.com.
2. Sixth Department of Infectious Diseases, Sixth People's Hospital of Zhengzhou, Zhengzhou 450015, China.
3. Sixth Department of Infectious Diseases, Sixth People's Hospital of Zhengzhou, Zhengzhou 450015, China. zhqx666@163.com.
- Publication Type:Journal Article
- Keywords:
clinical characteristics;
coronavirus disease 2019;
cough;
fever;
pneumonia;
severe acute respiratory syndrome coronavirus 2
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Betacoronavirus;
Child;
Child, Preschool;
China;
Coronavirus Infections;
diagnosis;
physiopathology;
Cough;
virology;
Female;
Fever;
virology;
Humans;
Leukocyte Count;
Male;
Middle Aged;
Pandemics;
Pneumonia, Viral;
diagnosis;
physiopathology;
Retrospective Studies;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2020;45(7):790-796
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To analyze the clinical characteristics of 71 patients with coronavirus disease 2019 (COVID-19).
METHODS:The general data, epidemiological data, laboratory tests, imaging examinations, and treatment of 71 patients with COVID-19 admitted to the Sixth People's Hospital of Zhengzhou from January 19, 2020 to March 3, 2020 were retrospectively analyzed.
RESULTS:Of the 71 COVID-19 patients, the ages were 4-84 (41.29±15.21) years, 38 (53.5%) patients were male, 33 (46.5%) were female, and 52 (73.2%) were in 22 clusters. The main clinical manifestations were fever (78.9%), cough (64.8%), and sputum (38.0%). The fever was mainly low and moderate, with 49 patients (69.0%) at 37.3-39.0 ℃. Most of the leukocytes, neutrophils, and lymphocytes were normal, accounting for 47 (66.2%), 51 (71.8%), and 51 (71.8%) patients, respectively; a few of them were decreased, accounting for 21 (29.6%), 16 (22.5%), and 20 (28.2%) patients, respectively. There were 38 (53.5%) and 31 (43.7%) patients with the decreased CD4 and CD8 T cell counts, respectively. There were 41 (57.7%), 38 (53.5%), 32 (45.1%), 26(36.6%), 22 (31.0%), 20 (28.2%), 14 (19.7%), 14 (19.7%), and 9 (12.7%) patients with the increased levels of C-reactive protein, erythrocyte sedimentation rate, procalcitonin, fibrinogen,interleukin 6, lactate dehydrogenase,-dimer,alanine aminotransferase, and aspartate aminotransferase, respectively. Of the 71 patients, the lung was involved in 60 (84.5%) patients, the double lung was involved in 47 (66.2%) patients, and the single lung was involved in 13 (18.3%) patients. The course of the disease was long, and the time from symptom onset to the second severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid negative transformation was (17.22±6.34) days.There were no significant differences in the incubation period (=-0.453, >0.05), the complicates (χ=0.042, >0.05), and the time from symptom onset to diagnosis (=-1.330, >0.05) in patients between the non-severe group and the severe group. The onset age, gender, SARS-CoV-2 nucleic acid negative time, lymphocyte count, -dimer, C-reactive protein, total bilirubin, direct bilirubin, lactate dehydrogenase, calcium ion, CD4 T cell count, CD8 T cell count, calcitonin, procalcitonin, and troponin were significantly different between the severe group and the non-severe group (all <0.05). Among the 71 patients, 4 (5.6%) patients were mild, 59 (83.1%) were normal, and 8 (11.3%) were severe or critical.
CONCLUSIONS:The aggregation phenomenon of COVID-19 is obvious. Fever and cough are the main clinical manifestations. White blood cells, neutrophils, and lymphocytes in the most patients in the early onset are normal. Most COVID-19 patients are light and ordinary type, with good prognosis.
