Effect of hypertension on prognosis in patients with pregnancyrelated acute kidney injury: A retrospective, propensity scorematched cohort study.
10.11817/j.issn.1672-7347.2020.180782
- Author:
Wenhang CHEN
1
;
Huihui LI
2
;
Quan ZHOU
3
;
Jing XUE
4
Author Information
1. Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008. wenhangchen@126.com.
2. Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008.
3. Department of Science and Education, First People's Hospital of Changde City, Changde Hunan 415000.
4. Department of Scientific Research & Institute of Hospital Administration, Xiangya Hospital, Central South University, Changsha 410008, China. 517332173@qq.com.
- Publication Type:Journal Article
- Keywords:
cohort study;
pregnancy-related acute kidney injury;
prognosis;
propensity score matching
- MeSH:
Acute Kidney Injury;
Cohort Studies;
Female;
Humans;
Hypertension;
complications;
Incidence;
Pregnancy;
Prognosis;
Propensity Score;
Retrospective Studies;
Risk Factors
- From:
Journal of Central South University(Medical Sciences)
2020;45(7):797-803
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:Hypertension is a serious complication of pregnancy-related acute kidney injury (PR-AKI). This study aimed to determine the effect of hypertension on the prognosis of PR-AKI, maternal outcomes, and fetal outcome.
METHODS:Patients with PR-AKI in a hospital from January 2008 to June 2018 were enrolled for this study. Patients with or without hypertension were grouped by 1꞉1 propensity matching score. The effect of hypertension on the prognosis of PR-AKI was evaluated by multivariate Cox regression before and after matching.
RESULTS:Of the 30 680 women who attended the Department of Obstetrics, 126 patients were diagnosed as PR-AKI, the incidence was 0.41%. The age was (29.04±2.32) years. There were 50 cases in the hypertension group, accounting for 39.68%. Using the propensity score method, 48 pairs of patients were successfully matched, and the covariates between the two groups were balanced. After matching and adjusting for relevant clinical factors, Cox regression analysis showed that risk of end-stage renal disease (ESRD) was increased in the hypertension group compared with the normal blood pressure group (HR=2.951, 95％ CI 1.067 to 8.275, =0.034). The risk of risk of adverse maternal outcome was increased (HR=2.815, 95% CI 1.271 to 6.233, =0.009), and the risk of fetal adverse outcome was increased (HR=1.437, 95% CI 1.028 to 4.623, =0.021).
CONCLUSIONS:Hypertension is an independent risk factor for ESRD, adverse maternal outcomes, and adverse fetal outcomes in the PR-AKI patients.
