Progress in the studies on the role of antisense long chain noncoding RNA in tumor development.
10.11817/j.issn.1672-7347.2020.180575
- Author:
Xiaowen QIU
1
;
Zhuo LEI
2
;
Daofeng LAI
3
;
Chaojian GONG
4
Author Information
1. Department of Stomatology, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, HaiKou 570208. qiuxiaowen@csu.edu.cn.
2. Department of Conservative Dentistry & Endodontics, Xiangya Stomatological Hospital, Central South University, Changsha 410078, China.
3. Department of Stomatology, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, HaiKou 570208.
4. Department of Stomatology, Second Xiangya Hospital, Central South University, Changsha 410011.
- Publication Type:Journal Article
- Keywords:
antisense long noncoding RNA;
malignant tumor;
molecular marker
- MeSH:
Biomarkers, Tumor;
Gene Expression Regulation;
Gene Expression Regulation, Neoplastic;
Humans;
MicroRNAs;
genetics;
Neoplasms;
genetics;
RNA, Long Noncoding;
genetics
- From:
Journal of Central South University(Medical Sciences)
2020;45(7):862-868
- CountryChina
- Language:English
-
Abstract:
Antisense long chain noncoding RNA (lncRNA) is a new class of RNA molecules. In recent years, antisense lncRNA has been found to play an important role in many life activities including tumorigenesis and development. It has become a hot topic in biological research in recent years. Because of the special structure, many antisense lncRNAs have specific expression in tumor tissues and are closely related to the clinical data of the patients. Thus, antisense lncRNA is a potential tumor molecular marker. Further functional studies have shown that lncRNA can participate in gene regulation by means of miRNA sponge and RBP binding to play an important role in tumor cell cycle, apoptosis, angiogenesis, invasion and metastasis. More studies on the mechanisms of antisense lncRNA in cancer are of great theoretical significance in understanding the etiology and pathogenesis of malignant tumors and RNA language. At the same time, antisense lncRNA is a molecular marker or a potential target for the early diagnosis of malignant tumors. The antisense lncRNA may have a broad clinical application prospect in the evaluation of therapeutic effect, prognosis and even gene therapy.
