IgG4-related diseases with autoimmune hemolytic anemia: A case report.
10.11817/j.issn.1672-7347.2020.190021
- Author:
Manxuan PEND
1
;
Lizhen YANG
2
;
Shangjie WU
3
Author Information
1. Department of Pulmonary and Critical Care Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China. pengmanxuan123@csu.edu.cn.
2. Department of Pulmonary and Critical Care Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.
3. Department of Pulmonary and Critical Care Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China. wushangjie@csu.edu.cn.
- Publication Type:Case Reports
- Keywords:
IgG4;
IgG4-related disease;
autoimmune hemolytic anemia;
glucocorticoid
- MeSH:
Anemia, Hemolytic, Autoimmune;
diagnosis;
drug therapy;
Autoimmune Diseases;
complications;
Biopsy;
Humans;
Immunoglobulin G;
Immunoglobulin G4-Related Disease;
complications;
diagnosis
- From:
Journal of Central South University(Medical Sciences)
2020;45(6):739-744
- CountryChina
- Language:English
-
Abstract:
IgG4-related disease (IgG4-RD) is a rare autoimmune fibrosis disease characterized by elevated serum IgG4 and tissues as well as organs infiltrated with IgG4-positive cells, resulting in swelling and damage.It is currently treated as first-line treatment with glucocorticoids. Autoimmune hemolytic anemia (AIHA) is also a relatively rare disease that caused by autoreactive erythrocyte antibodies. Although both are autoimmune-related diseases, they rarely overlap. The relationship between them is not clear. A case of IgG4-RD combined with AIHA is reported. The patient has shortness of breath, cough, and sputum after physical activity. Physical examination showed appearance of anemia, yellow staining of skin and sclera, palpable neck and multiple swollen lymph nodes. Laboratory examination, bone marrow biopsy, and lymph node biopsy confirmed the diagnosis. Therefore, clinicians should develop ideas and raise awareness of such diseases.
