Case control study of risk factors and ophthalmological outcomes of very low birth weight infants with Type 1 retinopathy of prematurity.

Tryphena Rachel NG; Inez B Wong; Cheryl S Ngo; Krishnamoorthy Niduvaje; Xin Ying Ngiam; Sonoko Sensaki; Le Ye Lee

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Case control study of risk factors and ophthalmological outcomes of very low birth weight infants with Type 1 retinopathy of prematurity.

Author: Tryphena Rachel NG ¹ ; Inez B WONG ² ; Cheryl S NGO ² ; Krishnamoorthy NIDUVAJE ³ ; Xin Ying NGIAM ³ ; Sonoko SENSAKI ³ ; Le Ye LEE ³
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1. Khoo Teck Puat-National University Children's Medical Institute, Singapore.
2. Department of Ophthalmology, National University Hospital, National University Health System, Singapore.
3. Department of Neonatology, National University Hospital, National University Health System, Singapore.
Publication Type:Journal Article
Keywords: chronic lung disease; strabismus; transfusion
From:Singapore medical journal 2020;61(8):426-434
CountrySingapore
Language:English
Abstract: INTRODUCTION:We evaluated the risk factors associated with Type 1 retinopathy of prematurity (ROP) in very low birth weight (VLBW) infants and compared ophthalmologic outcomes between cases with Type 1 ROP who received treatment and gestational age-matched controls with mild or no ROP not requiring treatment.
METHODS:This was a retrospective case-control study of VLBW infants born in National University Hospital, Singapore, from January 2001 to December 2013. 17 cases with Type 1 ROP were each matched for gestational age with controls who had either mild (below Stage 2) or no ROP. Antenatal, perinatal and postnatal variables, as well as childhood ophthalmologic outcomes, were collected from their clinical records and analysed.
RESULTS:The number of packed cell transfusions and highest fraction of inspired oxygen given at weeks 7-10 were found to be statistically significant on multivariate analysis (p = 0.045 and p = 0.049, respectively). None of the infants had blindness or retinal detachment, and there were no significant differences in refractive errors between the groups at 1-4 years of age. Strabismus at four years of age was more common in the group with Type 1 ROP (p = 0.023).
CONCLUSION:Increased episodes of blood transfusions and chronic lung disease requiring high oxygen supplementation at 7-10 weeks of life are significant risk factors associated with Type 1 ROP in VLBW infants in our study. Strabismus at four years is more common in this group of patients. This study highlights the importance of long-term ophthalmologic surveillance for these high-risk children.