New meroterpenoids and C-methylated flavonoid isolated from Baeckea frutescens.
10.1016/S1875-5364(20)30044-3
- Author:
Ji-Qin HOU
1
;
Heng ZHAO
1
;
Jiang-Hong YU
1
;
Ling-Jun CHEN
1
;
Hao WANG
2
Author Information
1. State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
2. State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: wanghao@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory;
Baeckea frutescens;
Meroterpenoid;
Myrtaceae
- From:
Chinese Journal of Natural Medicines (English Ed.)
2020;18(5):379-384
- CountryChina
- Language:English
-
Abstract:
Phytochemical investigation of the aerial parts of Baeckea frutescens resulted in the isolation of three new mono- or sesquiterpene-based meroterpenoids, frutescones S-U (1-3), and one pair of new (±)-5,7-dihydroxy-8-isobutyryl-6-methyldihydroflavonol (4). Their structures and absolute configurations were established by HR-ESI-MS, 1D and 2D NMR, and quantum chemical ECD calculation. Compound 1 exhibited inhibitory effect on NO production in LPS-activated RAW 264.7 macrophages with an IC value being 0.81 μmol·L.
