Alkaloid constituents from the fruits of Flueggea virosa.
10.1016/S1875-5364(20)30045-5
- Author:
Qiu-Jie XIE
1
,
2
;
Wei-Yan ZHANG
1
,
2
;
Zhen-Long WU
1
,
2
;
Ming-Tao XU
1
,
2
;
Qi-Fang HE
1
,
2
;
Xiao-Jun HUANG
1
,
2
;
Chun-Tao CHE
3
;
Ying WANG
1
,
4
;
Wen-Cai YE
1
,
5
Author Information
1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China
2. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Jinan University, Guangzhou 510632, China.
3. Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago 60612, United States.
4. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Jinan University, Guangzhou 510632, China. Electronic address: wangying_cpu@163.com.
5. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research, Jinan University, Guangzhou 510632, China. Electronic address: chywc@aliyun.com.
- Publication Type:Journal Article
- Keywords:
Biogenetical pathway;
Flueggea virosa;
Indole alkaloids;
Structural elucidation
- From:
Chinese Journal of Natural Medicines (English Ed.)
2020;18(5):385-392
- CountryChina
- Language:English
-
Abstract:
Three new indole alkaloids, flueindolines A-C (1-3), along with nine known alkaloids (4-12), were isolated from the fruits of Flueggea virosa (Roxb. ex Willd.) Voigt. Compounds 1 and 2 are two new fused tricyclic indole alkaloids possessing an unusual pyrido[1, 2-a]indole framework, and 3 presents a rare spiro (pyrrolizidinyl-oxindole) backbone. Their structures with absolute configurations were elucidated by means of comprehensive spectroscopic analysis, chemical calculation, as well as X-ray crystallography. Chiral resolution and absolute configuration determination of the known compounds 4, 10, and 11 were reported for the first time. The hypothetical biogenetical pathways of 1-3 were herein also proposed.
