Dendrobium officinale Kimura et Migo and American ginseng mixture: A Chinese herbal formulation for gut microbiota modulation.
10.1016/S1875-5364(20)30052-2
- Author:
Cheng-Zhi LIU
1
,
2
;
Wei CHEN
3
;
Mei-Xia WANG
1
,
2
;
Ying WANG
1
,
2
;
Li-Qing CHEN
3
;
Feng ZHAO
1
,
4
,
5
;
Ya SHI
1
,
2
;
Hui-Jun LIU
1
,
2
;
Xiao-Bing DOU
6
;
Chao LIU
7
;
Huan CHEN
1
,
8
Author Information
1. Key laboratory of Microbial technology and Bioinformatics of Zhejiang Province, Zhejiang Institute of Microbiology, Hangzhou 310012, China
2. NMPA Key laboratory for Testing and Risk Warning of Pharmaceutical Microbiology, Zhejiang Institute of Microbiology, Hangzhou 310012, China.
3. Hangzhou Huqing yu tang Traditional Chinese Medicine Mordernize Institute, Hangzhou 311100, China.
4. NMPA Key laboratory for Testing and Risk Warning of Pharmaceutical Microbiology, Zhejiang Institute of Microbiology, Hangzhou 310012, China
5. College of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
6. College of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
7. Department of Orthopaedics, Sir Sun Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China. Electronic address: liuchaozju@zju.edu.cn.
8. NMPA Key laboratory for Testing and Risk Warning of Pharmaceutical Microbiology, Zhejiang Institute of Microbiology, Hangzhou 310012, China. Electronic address: chenhuan7809@gmail.com.
- Publication Type:Journal Article
- Keywords:
16S rRNA;
American Ginseng;
Dendrobium officinale;
Gut Microbiota
- From:
Chinese Journal of Natural Medicines (English Ed.)
2020;18(6):446-459
- CountryChina
- Language:English
-
Abstract:
Dendrobium officinale Kimura et Migo (D. officinale) is a famous traditional Chinese medicine (TCM). A mixture of D. officinale and American ginseng has been shown to enhance cell-mediated immunity, humoral immunity, and monocyte/macrophage functions in mice. Here, the effects of a D. officinale and American ginseng mixture on the structure of gut microbial community in dogs were examined using high-throughput 16S rRNA gene amplicon sequencing. The data revealed that while the mixture did not change the diversity of gut microbial community significantly, differences among individuals were significantly reduced. Furthermore, the mixture-responsive operational taxonomic units (OTUs) exhibited a phase-dependent expression pattern. Fifty-five OTUs were found to exhibit a mixture-induced expression pattern, among which one third were short-chain fatty acid (SCFA)-producing genera and the others were probiotic genera included Lactobacillus spp., Sutterella, Alistipes, Anaerovorax, Bilophila, Coprococcus, Gordonibacter, Oscillibacter, among others. By contrast, 36% of the OTUs exhibiting a mixture-repressed expression pattern were disease-associated microorganisms, and six genera, namely Actinomyces, Escherichia/Shigella, Fusobacterium, Slackia, Streptococcus and Solobacterium, were associated with cancer. In addition, five genera were closely associated with diabetes, namely Collinsella, Rothia, Howardella, Slackia and Intestinibacter. Our results indicate that this D. officinale and American ginseng mixture may be used as a prebiotic agent to enhance SCFA-producing genera and prevent gut dysbiosis.
