Relationship of Expression of Circ_cgga162 with the Prognosis of Patients with Mantle Cell Lymphoma.
10.19746/j.cnki.issn.1009-2137.2020.03.026
- Author:
Yan LI
1
;
Zhen-Wei JIA
1
;
Ji-Xiang LIU
1
;
Jing-Wei YE
1
;
Xiao-Yang KONG
1
;
Zhi-Feng YANG
1
;
Xiao-Yan LIU
1
;
Jian-Min LUO
2
Author Information
1. Department of Hematology, The First Hospital of Handan City, Handan 056002, Hebei Province, China.
2. Department of Hematology, The Second Affilated Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China,E-mail: luojm315@163.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Kaplan-Meier Estimate;
Lymphoma, Mantle-Cell;
Multivariate Analysis;
Prognosis;
RNA, Circular;
genetics
- From:
Journal of Experimental Hematology
2020;28(3):876-880
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of Circ_cgga162 in serum of mantle cell lymphoma (MCL) patients and analyze its potential as a prognostic biomarker.
METHODS:The expression of Circ_cgga162 in 86 cases of mantle cell lymphoma and 50 cases of lymph node reactive hyperplasia (RH) were detected by real-time quantitative polymerase chain reaction (qRT-PCR). The relationship between the expression of Circ_cgga162 and clinicopathological features was analyzed by univariate analysis. The relationship of Circ_cgga162 expression with progression-free survival time and overall survival time was analyzed by Kaplan-Meier. The relationship between expression of Circ_cgga162 and prognosis of patients was analyzed by univariate and multivariate analysis.
RESULTS:The expression level of Circ_cgga162 in MCL patients was significantly higher than that in control (RH) group (P＜0.01). The expression of Circ_cgga162 not correlated with age, gender, B symptoms and LDH (all P＞0.05), but correlated with the expression of MCL International Prognostic Index (IPI), Ann Arbor stage, bone marrow infiltration and Ki67 (all P＜0.05). In addition, Kaplan-Meier analysis showed that the progression-free survival time and overall survival time of the MCL patients with high expression of Circ_cgga162 were significantly shorter than those of the MCL patients with low expression (P＜0.01). Univariate analysis showed that Ann Arbor stage, Circ_cgga162 expression, MIPI, bone marrow infiltration and Ki67 were the prognostic factors for MCL patients (all P＜0.05). Multivariate Cox regression analysis showed that Ann Arbor stage, Circ_cgga162 expression and MIPI were independent factors affecting the prognosis of MCL patients (all P＜0.05).
CONCLUSION:Circ_cgga162 is highly expressed in serum of patients MCL, which relates with the prognosis of MCL patients. Circ_cgga162 can be used as a potential prognostic marker and therapeutic target for MCL patients.
