Detection of Autoimmune Hemolytic Anemia Induced by Salvianolate and Evaluation of Blood Transfusion Efficacy.
10.19746/j.cnki.issn.1009-2137.2020.03.031
- Author:
Chun-Ya MA
1
;
Yuan-Yuan LUO
1
;
Lu YANG
1
;
Yan-Nan FENG
1
;
Xiao-Lin SUN
1
;
Wen-Juan ZOU
1
;
De-Qing WANG
2
;
Yang YU
3
Author Information
1. Department of Blood Transfusion, Center for Clinical Transfusion Medicine, Chinese PLA General Hospital, Beijing 100853, China.
2. Department of Blood Transfusion, Center for Clinical Transfusion Medicine, Chinese PLA General Hospital, Beijing 100853, China,E-mail: deqingw@vip.sina.com.
3. Department of Blood Transfusion, Center for Clinical Transfusion Medicine, Chinese PLA General Hospital, Beijing 100853, China,E-mail:yuyangpla301@163.com.
- Publication Type:Journal Article
- MeSH:
Anemia, Hemolytic, Autoimmune;
Blood Transfusion;
Erythrocytes;
Humans;
Plant Extracts;
Retrospective Studies
- From:
Journal of Experimental Hematology
2020;28(3):904-908
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the characteristics of autoimmune hemolytic anemia caused by salvianolate by antibody detection and clinical index monitoring.
METHODS:Micro-column gel anti-human globulin method was used for irregular antibody screening and antibody identification. Salvianolate, sodium creatine phosphate and levocarnitine were used to sensitize red blood cells that were compatible with the patient's plasma, and the RBCs were used to test drug antibody in patient plasma respectively. The patient's clinical examination of hemolysis index and blood transfusion effect were analyed retrospectively.
RESULTS:The patients were positive for irregular antibody screening, and there were antoanti-Ce antibodies in serum. The erythrocytes sensitized with salvianolate in the patient's serum were positive, while those sensitized with sodium creatine phosphate and levocarnitine were negative.
CONCLUSION:Salvianolate causes drug-induced autoimmune hemolytic anemia in this patient.
