Collagen Peptides Improve Lymphocyte Distribution in Peripheral Blood and T Lymphocyte Proliferation in Spleen of Mice under the Condition of Simulated Weightlessness.
10.19746/j.cnki.issn.1009-2137.2020.03.047
- Author:
Shao-Yan SI
1
;
Bing-Xin XU
1
;
Ying-Ying WU
1
;
Ya-Ya QIN
1
;
Ran DUAN
1
;
Shu-Jun SONG
2
Author Information
1. Center for Special Medicine and Experimental Research, Medical Center of PLA Strategic Support Force, Beijing 100101, China.
2. Center for Special Medicine and Experimental Research, Medical Center of PLA Strategic Support Force, Beijing 100101, China,E-mail：shuj80@126.com.
- Publication Type:Journal Article
- MeSH:
Animals;
CD8-Positive T-Lymphocytes;
Cell Proliferation;
Collagen;
Lymphocyte Count;
Mice;
Peptides;
Spleen;
Weightlessness;
Weightlessness Simulation
- From:
Journal of Experimental Hematology
2020;28(3):1001-1005
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate whether collagen peptides can improve the immune functions of mice under the condition of simulated weightlessness.
METHODS:Mouse tail-suspension model was used to simulate the effects of weightlessness. Tail-suspended mice were intraperitoneally injected with 600 mg collagen peptides per kilogram body weight once a day for 10 days. Then, the mice were killed, and white blood cells were counted and classified. Lymphocyte subsets and T lymphocyte proliferations in spleens were analyzed.
RESULTS:Compared with normal control group, total and differential count of leukocytes, lymphocytes, T cells，CD4 and CD8 T cells, B cells and NK cells, and splenic T lymphocyte proliferation all decreased in the weightlessness simulated mice (P＜0.05). Except for NK cells, the above-mentioned parameters were increased after administration of collagen peptides, and some of the parameters were recovered to the levels of normal control mice (P＜0.05).
CONCLUSION:Collagen peptides can effectively improve peripheral blood lymphocyte distributions and T lymphocyte proliferations of mice under the condition of simulated weightlessness. This study nay provid the experimental basis for improvement of immune functions of astronauts.
